A Small Step, a Giant Leap: Somatic Hypermutation of a Single Amino Acid Leads to Anti-La Autoreactivity

The anti-La mab 312B, which was established by hybridoma technology from human-La transgenic mice after adoptive transfer of anti-human La T cells, immunoprecipitates both native eukaryotic human and murine La protein. Therefore, it represents a true anti-La autoantibody. During maturation, the anti...

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Detalles Bibliográficos
Autores principales: Bartsch, Tabea, Arndt, Claudia, Loureiro, Liliana R., Kegler, Alexandra, Puentes-Cala, Edinson, Soto, Javier Andrés, Kurien, Biji T., Feldmann, Anja, Berndt, Nicole, Bachmann, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584381/
https://www.ncbi.nlm.nih.gov/pubmed/34769474
http://dx.doi.org/10.3390/ijms222112046

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