Cargando…

A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan

It remains unclear to what extent newborn hearing screening (NHS) detects congenital cytomegalovirus (cCMV)-associated sensorineural hearing loss (SNHL) in Japan. This study aimed to clarify the NHS results and audiological characteristics of patients with cCMV-associated SNHL. A total of 541 indivi...

Descripción completa

Detalles Bibliográficos
Autores principales: Minami, Shujiro Bando, Yamanobe, Yoshiharu, Nakano, Atsuko, Sakamoto, Hirokazu, Masuda, Sawako, Takiguchi, Tetsuya, Katsunuma, Sayaka, Sugiuchi, Tomoko, Morita, Noriko, Kaga, Kimitaka, Matsunaga, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584481/
https://www.ncbi.nlm.nih.gov/pubmed/34768578
http://dx.doi.org/10.3390/jcm10215056
_version_ 1784597459684556800
author Minami, Shujiro Bando
Yamanobe, Yoshiharu
Nakano, Atsuko
Sakamoto, Hirokazu
Masuda, Sawako
Takiguchi, Tetsuya
Katsunuma, Sayaka
Sugiuchi, Tomoko
Morita, Noriko
Kaga, Kimitaka
Matsunaga, Tatsuo
author_facet Minami, Shujiro Bando
Yamanobe, Yoshiharu
Nakano, Atsuko
Sakamoto, Hirokazu
Masuda, Sawako
Takiguchi, Tetsuya
Katsunuma, Sayaka
Sugiuchi, Tomoko
Morita, Noriko
Kaga, Kimitaka
Matsunaga, Tatsuo
author_sort Minami, Shujiro Bando
collection PubMed
description It remains unclear to what extent newborn hearing screening (NHS) detects congenital cytomegalovirus (cCMV)-associated sensorineural hearing loss (SNHL) in Japan. This study aimed to clarify the NHS results and audiological characteristics of patients with cCMV-associated SNHL. A total of 541 individuals with unilateral or bilateral hearing loss of unknown etiology were examined for cCMV infection. cCMV infection was defined by the presence of CMV DNA in the dried umbilical cord detected using real-time quantitative PCR. NHS results and audiological data were retrospectively obtained from medical records. Forty-four cases (8.1%) were positive for cCMV infection. Of them, 33 cases underwent NHS and 13 cases (39.4%) passed NHS bilaterally. The pure-tone audiograms of 21 patients were obtained. There were seven cases of unilateral SNHL, five cases of asymmetric bilateral SNHL, and nine cases of symmetric bilateral SNHL. cCMV-related hearing loss is highly heterogeneous, and there is a high risk of missing this condition through NHS.
format Online
Article
Text
id pubmed-8584481
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85844812021-11-12 A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan Minami, Shujiro Bando Yamanobe, Yoshiharu Nakano, Atsuko Sakamoto, Hirokazu Masuda, Sawako Takiguchi, Tetsuya Katsunuma, Sayaka Sugiuchi, Tomoko Morita, Noriko Kaga, Kimitaka Matsunaga, Tatsuo J Clin Med Article It remains unclear to what extent newborn hearing screening (NHS) detects congenital cytomegalovirus (cCMV)-associated sensorineural hearing loss (SNHL) in Japan. This study aimed to clarify the NHS results and audiological characteristics of patients with cCMV-associated SNHL. A total of 541 individuals with unilateral or bilateral hearing loss of unknown etiology were examined for cCMV infection. cCMV infection was defined by the presence of CMV DNA in the dried umbilical cord detected using real-time quantitative PCR. NHS results and audiological data were retrospectively obtained from medical records. Forty-four cases (8.1%) were positive for cCMV infection. Of them, 33 cases underwent NHS and 13 cases (39.4%) passed NHS bilaterally. The pure-tone audiograms of 21 patients were obtained. There were seven cases of unilateral SNHL, five cases of asymmetric bilateral SNHL, and nine cases of symmetric bilateral SNHL. cCMV-related hearing loss is highly heterogeneous, and there is a high risk of missing this condition through NHS. MDPI 2021-10-29 /pmc/articles/PMC8584481/ /pubmed/34768578 http://dx.doi.org/10.3390/jcm10215056 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Minami, Shujiro Bando
Yamanobe, Yoshiharu
Nakano, Atsuko
Sakamoto, Hirokazu
Masuda, Sawako
Takiguchi, Tetsuya
Katsunuma, Sayaka
Sugiuchi, Tomoko
Morita, Noriko
Kaga, Kimitaka
Matsunaga, Tatsuo
A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan
title A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan
title_full A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan
title_fullStr A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan
title_full_unstemmed A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan
title_short A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan
title_sort high risk of missing congenital cytomegalovirus-associated hearing loss through newborn hearing screening in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584481/
https://www.ncbi.nlm.nih.gov/pubmed/34768578
http://dx.doi.org/10.3390/jcm10215056
work_keys_str_mv AT minamishujirobando ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT yamanobeyoshiharu ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT nakanoatsuko ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT sakamotohirokazu ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT masudasawako ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT takiguchitetsuya ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT katsunumasayaka ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT sugiuchitomoko ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT moritanoriko ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT kagakimitaka ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT matsunagatatsuo ahighriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT minamishujirobando highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT yamanobeyoshiharu highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT nakanoatsuko highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT sakamotohirokazu highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT masudasawako highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT takiguchitetsuya highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT katsunumasayaka highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT sugiuchitomoko highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT moritanoriko highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT kagakimitaka highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan
AT matsunagatatsuo highriskofmissingcongenitalcytomegalovirusassociatedhearinglossthroughnewbornhearingscreeninginjapan