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A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan
It remains unclear to what extent newborn hearing screening (NHS) detects congenital cytomegalovirus (cCMV)-associated sensorineural hearing loss (SNHL) in Japan. This study aimed to clarify the NHS results and audiological characteristics of patients with cCMV-associated SNHL. A total of 541 indivi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584481/ https://www.ncbi.nlm.nih.gov/pubmed/34768578 http://dx.doi.org/10.3390/jcm10215056 |
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author | Minami, Shujiro Bando Yamanobe, Yoshiharu Nakano, Atsuko Sakamoto, Hirokazu Masuda, Sawako Takiguchi, Tetsuya Katsunuma, Sayaka Sugiuchi, Tomoko Morita, Noriko Kaga, Kimitaka Matsunaga, Tatsuo |
author_facet | Minami, Shujiro Bando Yamanobe, Yoshiharu Nakano, Atsuko Sakamoto, Hirokazu Masuda, Sawako Takiguchi, Tetsuya Katsunuma, Sayaka Sugiuchi, Tomoko Morita, Noriko Kaga, Kimitaka Matsunaga, Tatsuo |
author_sort | Minami, Shujiro Bando |
collection | PubMed |
description | It remains unclear to what extent newborn hearing screening (NHS) detects congenital cytomegalovirus (cCMV)-associated sensorineural hearing loss (SNHL) in Japan. This study aimed to clarify the NHS results and audiological characteristics of patients with cCMV-associated SNHL. A total of 541 individuals with unilateral or bilateral hearing loss of unknown etiology were examined for cCMV infection. cCMV infection was defined by the presence of CMV DNA in the dried umbilical cord detected using real-time quantitative PCR. NHS results and audiological data were retrospectively obtained from medical records. Forty-four cases (8.1%) were positive for cCMV infection. Of them, 33 cases underwent NHS and 13 cases (39.4%) passed NHS bilaterally. The pure-tone audiograms of 21 patients were obtained. There were seven cases of unilateral SNHL, five cases of asymmetric bilateral SNHL, and nine cases of symmetric bilateral SNHL. cCMV-related hearing loss is highly heterogeneous, and there is a high risk of missing this condition through NHS. |
format | Online Article Text |
id | pubmed-8584481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85844812021-11-12 A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan Minami, Shujiro Bando Yamanobe, Yoshiharu Nakano, Atsuko Sakamoto, Hirokazu Masuda, Sawako Takiguchi, Tetsuya Katsunuma, Sayaka Sugiuchi, Tomoko Morita, Noriko Kaga, Kimitaka Matsunaga, Tatsuo J Clin Med Article It remains unclear to what extent newborn hearing screening (NHS) detects congenital cytomegalovirus (cCMV)-associated sensorineural hearing loss (SNHL) in Japan. This study aimed to clarify the NHS results and audiological characteristics of patients with cCMV-associated SNHL. A total of 541 individuals with unilateral or bilateral hearing loss of unknown etiology were examined for cCMV infection. cCMV infection was defined by the presence of CMV DNA in the dried umbilical cord detected using real-time quantitative PCR. NHS results and audiological data were retrospectively obtained from medical records. Forty-four cases (8.1%) were positive for cCMV infection. Of them, 33 cases underwent NHS and 13 cases (39.4%) passed NHS bilaterally. The pure-tone audiograms of 21 patients were obtained. There were seven cases of unilateral SNHL, five cases of asymmetric bilateral SNHL, and nine cases of symmetric bilateral SNHL. cCMV-related hearing loss is highly heterogeneous, and there is a high risk of missing this condition through NHS. MDPI 2021-10-29 /pmc/articles/PMC8584481/ /pubmed/34768578 http://dx.doi.org/10.3390/jcm10215056 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Minami, Shujiro Bando Yamanobe, Yoshiharu Nakano, Atsuko Sakamoto, Hirokazu Masuda, Sawako Takiguchi, Tetsuya Katsunuma, Sayaka Sugiuchi, Tomoko Morita, Noriko Kaga, Kimitaka Matsunaga, Tatsuo A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan |
title | A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan |
title_full | A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan |
title_fullStr | A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan |
title_full_unstemmed | A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan |
title_short | A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan |
title_sort | high risk of missing congenital cytomegalovirus-associated hearing loss through newborn hearing screening in japan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584481/ https://www.ncbi.nlm.nih.gov/pubmed/34768578 http://dx.doi.org/10.3390/jcm10215056 |
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