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The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer

The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes of its concentrations are followed by respective alterations of thyroid hormone levels. We evaluated the effect of recombinant human TSH (rhTSH) on sclerostin and other bone markers in 29 patients after total...

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Autores principales: Zygmunt, Arkadiusz, Krawczyk-Rusiecka, Kinga, Skowrońska-Jóźwiak, Elżbieta, Wojciechowska-Durczyńska, Katarzyna, Głowacka, Ewa, Adamczewski, Zbigniew, Lewiński, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584503/
https://www.ncbi.nlm.nih.gov/pubmed/34768424
http://dx.doi.org/10.3390/jcm10214905
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author Zygmunt, Arkadiusz
Krawczyk-Rusiecka, Kinga
Skowrońska-Jóźwiak, Elżbieta
Wojciechowska-Durczyńska, Katarzyna
Głowacka, Ewa
Adamczewski, Zbigniew
Lewiński, Andrzej
author_facet Zygmunt, Arkadiusz
Krawczyk-Rusiecka, Kinga
Skowrońska-Jóźwiak, Elżbieta
Wojciechowska-Durczyńska, Katarzyna
Głowacka, Ewa
Adamczewski, Zbigniew
Lewiński, Andrzej
author_sort Zygmunt, Arkadiusz
collection PubMed
description The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes of its concentrations are followed by respective alterations of thyroid hormone levels. We evaluated the effect of recombinant human TSH (rhTSH) on sclerostin and other bone markers in 29 patients after total thyroidectomy for differentiated thyroid cancer (DTC), without any signs of disease recurrence, who received L-thyroxine, most at non-suppressive doses. For two consecutive days, the patients were administered a standard dose of 0.9 mg rhTSH, i.m. Concentrations of sclerostin, osteocalcin, β-CrossLaps, PTH, and some other parameters, were measured before and five days after the first rhTSH administration. The greater the increase in TSH concentration (∆TSH), the greater the decrease in: ∆sclerostin (r = −0.672; p < 0.001), ∆β-CrossLaps (r = −0.580; p < 0.001) and ∆osteocalcin (r = −0.405; p = 0.029) levels, were recorded. The degree of TSH increase depended on the baseline PTH (r = 0.651; p < 0.001), age, and creatinine concentrations. rhTSH strongly inhibited bone turnover, thus, TSH—independently of thyroid hormones—exerted a direct protective effect on bone metabolism. Baseline PTH affected the magnitude of TSH increase and the degree of lowering in sclerostin and β-CrossLaps that suggest factors affecting PTH may play a role in the effect of TSH on the bone.
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spelling pubmed-85845032021-11-12 The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer Zygmunt, Arkadiusz Krawczyk-Rusiecka, Kinga Skowrońska-Jóźwiak, Elżbieta Wojciechowska-Durczyńska, Katarzyna Głowacka, Ewa Adamczewski, Zbigniew Lewiński, Andrzej J Clin Med Article The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes of its concentrations are followed by respective alterations of thyroid hormone levels. We evaluated the effect of recombinant human TSH (rhTSH) on sclerostin and other bone markers in 29 patients after total thyroidectomy for differentiated thyroid cancer (DTC), without any signs of disease recurrence, who received L-thyroxine, most at non-suppressive doses. For two consecutive days, the patients were administered a standard dose of 0.9 mg rhTSH, i.m. Concentrations of sclerostin, osteocalcin, β-CrossLaps, PTH, and some other parameters, were measured before and five days after the first rhTSH administration. The greater the increase in TSH concentration (∆TSH), the greater the decrease in: ∆sclerostin (r = −0.672; p < 0.001), ∆β-CrossLaps (r = −0.580; p < 0.001) and ∆osteocalcin (r = −0.405; p = 0.029) levels, were recorded. The degree of TSH increase depended on the baseline PTH (r = 0.651; p < 0.001), age, and creatinine concentrations. rhTSH strongly inhibited bone turnover, thus, TSH—independently of thyroid hormones—exerted a direct protective effect on bone metabolism. Baseline PTH affected the magnitude of TSH increase and the degree of lowering in sclerostin and β-CrossLaps that suggest factors affecting PTH may play a role in the effect of TSH on the bone. MDPI 2021-10-24 /pmc/articles/PMC8584503/ /pubmed/34768424 http://dx.doi.org/10.3390/jcm10214905 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zygmunt, Arkadiusz
Krawczyk-Rusiecka, Kinga
Skowrońska-Jóźwiak, Elżbieta
Wojciechowska-Durczyńska, Katarzyna
Głowacka, Ewa
Adamczewski, Zbigniew
Lewiński, Andrzej
The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_full The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_fullStr The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_full_unstemmed The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_short The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_sort effect of recombinant human tsh on sclerostin and other selected bone markers in patients after total thyroidectomy for differentiated thyroid cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584503/
https://www.ncbi.nlm.nih.gov/pubmed/34768424
http://dx.doi.org/10.3390/jcm10214905
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