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The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy

Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5–15 ng/mL who have a suspicious prostate lesio...

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Autores principales: Lee, Chung Un, Choi, Joongwon, Sung, Si Hyun, Chung, Jae Hoon, Song, Wan, Kang, Minyong, Sung, Hyun Hwan, Jeong, Byong Chang, Seo, Seong Il, Jeon, Seong Soo, Lee, Hyun Moo, Jeon, Hwang Gyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584506/
https://www.ncbi.nlm.nih.gov/pubmed/34768322
http://dx.doi.org/10.3390/jcm10214804
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author Lee, Chung Un
Choi, Joongwon
Sung, Si Hyun
Chung, Jae Hoon
Song, Wan
Kang, Minyong
Sung, Hyun Hwan
Jeong, Byong Chang
Seo, Seong Il
Jeon, Seong Soo
Lee, Hyun Moo
Jeon, Hwang Gyun
author_facet Lee, Chung Un
Choi, Joongwon
Sung, Si Hyun
Chung, Jae Hoon
Song, Wan
Kang, Minyong
Sung, Hyun Hwan
Jeong, Byong Chang
Seo, Seong Il
Jeon, Seong Soo
Lee, Hyun Moo
Jeon, Hwang Gyun
author_sort Lee, Chung Un
collection PubMed
description Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5–15 ng/mL who have a suspicious prostate lesion (with the Prostate Imaging Reporting and Data System (PI-RADS) ≥ 3) on multiparametric MRI (mpMRI) between January 2016 and December 2018. We analyzed biopsy results by PI-RADS score and biopsy methods (systematic, targeted, and combination biopsy). Results: Of the 711 total patients, an average of 4.0 ± 1.8 targeted and 8.6 ± 3.1 additional systematic biopsies were performed. The additional systematic biopsies were sampled outside the targeted biopsy area. The combination biopsies detected more csPCa (201 patients, 28.3%) than did the targeted (175 patients, 24.6%) or systematic (124 patients, 17.4%) biopsies alone (p < 0.001). In the initial biopsy samples, there was a 7% increase in the detection of csPCa than in targeted biopsy (62% to 69%). It increased by 11% in repeat biopsy (46% to 57%). There was no statistical significance in both groups (p = 0.3174). Conclusions: Combination biopsy has the benefit of detecting csPCa in both initial and repeat biopsy when there is a suspicious lesion on mpMRI.
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spelling pubmed-85845062021-11-12 The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy Lee, Chung Un Choi, Joongwon Sung, Si Hyun Chung, Jae Hoon Song, Wan Kang, Minyong Sung, Hyun Hwan Jeong, Byong Chang Seo, Seong Il Jeon, Seong Soo Lee, Hyun Moo Jeon, Hwang Gyun J Clin Med Article Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5–15 ng/mL who have a suspicious prostate lesion (with the Prostate Imaging Reporting and Data System (PI-RADS) ≥ 3) on multiparametric MRI (mpMRI) between January 2016 and December 2018. We analyzed biopsy results by PI-RADS score and biopsy methods (systematic, targeted, and combination biopsy). Results: Of the 711 total patients, an average of 4.0 ± 1.8 targeted and 8.6 ± 3.1 additional systematic biopsies were performed. The additional systematic biopsies were sampled outside the targeted biopsy area. The combination biopsies detected more csPCa (201 patients, 28.3%) than did the targeted (175 patients, 24.6%) or systematic (124 patients, 17.4%) biopsies alone (p < 0.001). In the initial biopsy samples, there was a 7% increase in the detection of csPCa than in targeted biopsy (62% to 69%). It increased by 11% in repeat biopsy (46% to 57%). There was no statistical significance in both groups (p = 0.3174). Conclusions: Combination biopsy has the benefit of detecting csPCa in both initial and repeat biopsy when there is a suspicious lesion on mpMRI. MDPI 2021-10-20 /pmc/articles/PMC8584506/ /pubmed/34768322 http://dx.doi.org/10.3390/jcm10214804 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Chung Un
Choi, Joongwon
Sung, Si Hyun
Chung, Jae Hoon
Song, Wan
Kang, Minyong
Sung, Hyun Hwan
Jeong, Byong Chang
Seo, Seong Il
Jeon, Seong Soo
Lee, Hyun Moo
Jeon, Hwang Gyun
The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_full The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_fullStr The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_full_unstemmed The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_short The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_sort role of prostate combination biopsy consisting of targeted and additional systematic biopsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584506/
https://www.ncbi.nlm.nih.gov/pubmed/34768322
http://dx.doi.org/10.3390/jcm10214804
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