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Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national ho...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584564/ https://www.ncbi.nlm.nih.gov/pubmed/34768409 http://dx.doi.org/10.3390/jcm10214889 |
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author | de Miguel-Diez, Javier Lopez-Herranz, Marta Hernandez-Barrera, Valentin de Miguel-Yanes, Jose M. Perez-Farinos, Napoleon Wärnberg, Julia Carabantes-Alarcon, David Jimenez-Garcia, Rodrigo Lopez-de-Andres, Ana |
author_facet | de Miguel-Diez, Javier Lopez-Herranz, Marta Hernandez-Barrera, Valentin de Miguel-Yanes, Jose M. Perez-Farinos, Napoleon Wärnberg, Julia Carabantes-Alarcon, David Jimenez-Garcia, Rodrigo Lopez-de-Andres, Ana |
author_sort | de Miguel-Diez, Javier |
collection | PubMed |
description | Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; p < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women. |
format | Online Article Text |
id | pubmed-8584564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85845642021-11-12 Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data de Miguel-Diez, Javier Lopez-Herranz, Marta Hernandez-Barrera, Valentin de Miguel-Yanes, Jose M. Perez-Farinos, Napoleon Wärnberg, Julia Carabantes-Alarcon, David Jimenez-Garcia, Rodrigo Lopez-de-Andres, Ana J Clin Med Article Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; p < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women. MDPI 2021-10-23 /pmc/articles/PMC8584564/ /pubmed/34768409 http://dx.doi.org/10.3390/jcm10214889 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Miguel-Diez, Javier Lopez-Herranz, Marta Hernandez-Barrera, Valentin de Miguel-Yanes, Jose M. Perez-Farinos, Napoleon Wärnberg, Julia Carabantes-Alarcon, David Jimenez-Garcia, Rodrigo Lopez-de-Andres, Ana Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title | Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_full | Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_fullStr | Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_full_unstemmed | Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_short | Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_sort | community-acquired pneumonia among patients with copd in spain from 2016 to 2019. cohort study assessing sex differences in the incidence and outcomes using hospital discharge data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584564/ https://www.ncbi.nlm.nih.gov/pubmed/34768409 http://dx.doi.org/10.3390/jcm10214889 |
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