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Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data

Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national ho...

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Autores principales: de Miguel-Diez, Javier, Lopez-Herranz, Marta, Hernandez-Barrera, Valentin, de Miguel-Yanes, Jose M., Perez-Farinos, Napoleon, Wärnberg, Julia, Carabantes-Alarcon, David, Jimenez-Garcia, Rodrigo, Lopez-de-Andres, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584564/
https://www.ncbi.nlm.nih.gov/pubmed/34768409
http://dx.doi.org/10.3390/jcm10214889
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author de Miguel-Diez, Javier
Lopez-Herranz, Marta
Hernandez-Barrera, Valentin
de Miguel-Yanes, Jose M.
Perez-Farinos, Napoleon
Wärnberg, Julia
Carabantes-Alarcon, David
Jimenez-Garcia, Rodrigo
Lopez-de-Andres, Ana
author_facet de Miguel-Diez, Javier
Lopez-Herranz, Marta
Hernandez-Barrera, Valentin
de Miguel-Yanes, Jose M.
Perez-Farinos, Napoleon
Wärnberg, Julia
Carabantes-Alarcon, David
Jimenez-Garcia, Rodrigo
Lopez-de-Andres, Ana
author_sort de Miguel-Diez, Javier
collection PubMed
description Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; p < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women.
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spelling pubmed-85845642021-11-12 Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data de Miguel-Diez, Javier Lopez-Herranz, Marta Hernandez-Barrera, Valentin de Miguel-Yanes, Jose M. Perez-Farinos, Napoleon Wärnberg, Julia Carabantes-Alarcon, David Jimenez-Garcia, Rodrigo Lopez-de-Andres, Ana J Clin Med Article Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; p < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women. MDPI 2021-10-23 /pmc/articles/PMC8584564/ /pubmed/34768409 http://dx.doi.org/10.3390/jcm10214889 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Miguel-Diez, Javier
Lopez-Herranz, Marta
Hernandez-Barrera, Valentin
de Miguel-Yanes, Jose M.
Perez-Farinos, Napoleon
Wärnberg, Julia
Carabantes-Alarcon, David
Jimenez-Garcia, Rodrigo
Lopez-de-Andres, Ana
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_full Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_fullStr Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_full_unstemmed Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_short Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_sort community-acquired pneumonia among patients with copd in spain from 2016 to 2019. cohort study assessing sex differences in the incidence and outcomes using hospital discharge data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584564/
https://www.ncbi.nlm.nih.gov/pubmed/34768409
http://dx.doi.org/10.3390/jcm10214889
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