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Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine
In 2020, SARS-COV-2 put health systems under unprecedented resource and manpower pressure leading to significant number of deaths. Expectedly, researchers sought to shed light on the pathophysiologic background of this novel disease (COVID-19) as well as to facilitate the design of effective therape...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584586/ https://www.ncbi.nlm.nih.gov/pubmed/34768648 http://dx.doi.org/10.3390/jcm10215128 |
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author | Vrachatis, Dimitrios A. Papathanasiou, Konstantinos A. Giotaki, Sotiria G. Raisakis, Konstantinos Kossyvakis, Charalampos Kaoukis, Andreas Kolokathis, Fotis Deftereos, Gerasimos Iliodromitis, Konstantinos E. Avramides, Dimitrios Bogossian, Harilaos Siasos, Gerasimos Giannopoulos, George Reimers, Bernhard Lansky, Alexandra Tardif, Jean-Claude Deftereos, Spyridon |
author_facet | Vrachatis, Dimitrios A. Papathanasiou, Konstantinos A. Giotaki, Sotiria G. Raisakis, Konstantinos Kossyvakis, Charalampos Kaoukis, Andreas Kolokathis, Fotis Deftereos, Gerasimos Iliodromitis, Konstantinos E. Avramides, Dimitrios Bogossian, Harilaos Siasos, Gerasimos Giannopoulos, George Reimers, Bernhard Lansky, Alexandra Tardif, Jean-Claude Deftereos, Spyridon |
author_sort | Vrachatis, Dimitrios A. |
collection | PubMed |
description | In 2020, SARS-COV-2 put health systems under unprecedented resource and manpower pressure leading to significant number of deaths. Expectedly, researchers sought to shed light on the pathophysiologic background of this novel disease (COVID-19) as well as to facilitate the design of effective therapeutic modalities. Indeed, early enough the pivotal role of inflammatory and thrombotic pathways in SARS-COV-2 infection has been illustrated. The purpose of this article is to briefly present the epidemiologic and clinical features of COVID-19, analyze the pathophysiologic importance of immunologic dysregulation and hypercoagulability in developing disease complications and finally to present an up-to-date systematic review of colchicine’s immunomodulating capacity in view of hindering coronavirus complications. |
format | Online Article Text |
id | pubmed-8584586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85845862021-11-12 Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine Vrachatis, Dimitrios A. Papathanasiou, Konstantinos A. Giotaki, Sotiria G. Raisakis, Konstantinos Kossyvakis, Charalampos Kaoukis, Andreas Kolokathis, Fotis Deftereos, Gerasimos Iliodromitis, Konstantinos E. Avramides, Dimitrios Bogossian, Harilaos Siasos, Gerasimos Giannopoulos, George Reimers, Bernhard Lansky, Alexandra Tardif, Jean-Claude Deftereos, Spyridon J Clin Med Review In 2020, SARS-COV-2 put health systems under unprecedented resource and manpower pressure leading to significant number of deaths. Expectedly, researchers sought to shed light on the pathophysiologic background of this novel disease (COVID-19) as well as to facilitate the design of effective therapeutic modalities. Indeed, early enough the pivotal role of inflammatory and thrombotic pathways in SARS-COV-2 infection has been illustrated. The purpose of this article is to briefly present the epidemiologic and clinical features of COVID-19, analyze the pathophysiologic importance of immunologic dysregulation and hypercoagulability in developing disease complications and finally to present an up-to-date systematic review of colchicine’s immunomodulating capacity in view of hindering coronavirus complications. MDPI 2021-10-31 /pmc/articles/PMC8584586/ /pubmed/34768648 http://dx.doi.org/10.3390/jcm10215128 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vrachatis, Dimitrios A. Papathanasiou, Konstantinos A. Giotaki, Sotiria G. Raisakis, Konstantinos Kossyvakis, Charalampos Kaoukis, Andreas Kolokathis, Fotis Deftereos, Gerasimos Iliodromitis, Konstantinos E. Avramides, Dimitrios Bogossian, Harilaos Siasos, Gerasimos Giannopoulos, George Reimers, Bernhard Lansky, Alexandra Tardif, Jean-Claude Deftereos, Spyridon Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine |
title | Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine |
title_full | Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine |
title_fullStr | Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine |
title_full_unstemmed | Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine |
title_short | Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine |
title_sort | immunologic dysregulation and hypercoagulability as a pathophysiologic background in covid-19 infection and the immunomodulating role of colchicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584586/ https://www.ncbi.nlm.nih.gov/pubmed/34768648 http://dx.doi.org/10.3390/jcm10215128 |
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