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Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management

Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving...

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Autores principales: Zając, Hanna, Turno-Kręcicka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584626/
https://www.ncbi.nlm.nih.gov/pubmed/34768694
http://dx.doi.org/10.3390/jcm10215174
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author Zając, Hanna
Turno-Kręcicka, Anna
author_facet Zając, Hanna
Turno-Kręcicka, Anna
author_sort Zając, Hanna
collection PubMed
description Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving due to the clinical phenotypes recently described in the literature and increasing focus on the detection of subclinical inflammation to enable correct therapeutic decisions. The first line treatment is azathioprine, followed by various immunosuppressive and biological agents as alternatives in severe or refractory cases. This review summarizes scientific articles about the etiology of, diagnostic tools for and treatment of the ocular manifestations of Behçet’s disease available in the PubMed database from 1 January 2016 to 1 May 2021. A multidisciplinary approach is necessary to effectively prevent permanent damage and thus improve the life quality of the patients. Therefore, it is crucial to raise awareness of the common clusters of symptoms, use of modern imaging methods, such as ocular computed tomography and fluorescein angiography, and novelty treatment algorithms to enable early diagnosis and appropriate management.
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spelling pubmed-85846262021-11-12 Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management Zając, Hanna Turno-Kręcicka, Anna J Clin Med Review Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving due to the clinical phenotypes recently described in the literature and increasing focus on the detection of subclinical inflammation to enable correct therapeutic decisions. The first line treatment is azathioprine, followed by various immunosuppressive and biological agents as alternatives in severe or refractory cases. This review summarizes scientific articles about the etiology of, diagnostic tools for and treatment of the ocular manifestations of Behçet’s disease available in the PubMed database from 1 January 2016 to 1 May 2021. A multidisciplinary approach is necessary to effectively prevent permanent damage and thus improve the life quality of the patients. Therefore, it is crucial to raise awareness of the common clusters of symptoms, use of modern imaging methods, such as ocular computed tomography and fluorescein angiography, and novelty treatment algorithms to enable early diagnosis and appropriate management. MDPI 2021-11-05 /pmc/articles/PMC8584626/ /pubmed/34768694 http://dx.doi.org/10.3390/jcm10215174 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zając, Hanna
Turno-Kręcicka, Anna
Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_full Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_fullStr Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_full_unstemmed Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_short Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_sort ocular manifestations of behçet’s disease: an update on diagnostic challenges and disease management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584626/
https://www.ncbi.nlm.nih.gov/pubmed/34768694
http://dx.doi.org/10.3390/jcm10215174
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