The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells

Mutations in the PINK1 and PRKN genes are the most common cause of early-onset familial Parkinson disease. These genes code for the PINK1 and Parkin proteins, respectively, which are involved in the degradation of dysfunctional mitochondria through mitophagy. An early step in PINK1 –Parkin mediated...

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Detalles Bibliográficos
Autores principales: Bradshaw, Aaron V., Campbell, Philip, Schapira, Anthony H. V., Morris, Huw R., Taanman, Jan-Willem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584748/
https://www.ncbi.nlm.nih.gov/pubmed/34762687
http://dx.doi.org/10.1371/journal.pone.0259903

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