Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans

Genetic variants in the asialoglycoprotein receptor 1 (ASGR1) are associated with a reduced risk of cardiovascular disease (CVD) in humans. However, the underlying molecular mechanism remains elusive. Given the cardiovascular similarities between pigs and humans, we generated ASGR1-deficient pigs us...

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Detalles Bibliográficos
Autores principales: Xie, Baocai, Shi, Xiaochen, Li, Yan, Xia, Bo, Zhou, Jia, Du, Minjie, Xing, Xiangyang, Bai, Liang, Liu, Enqi, Alvarez, Fernando, Jin, Long, Deng, Shaoping, Mitchell, Grant A., Pan, Dengke, Li, Mingzhou, Wu, Jiangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584755/
https://www.ncbi.nlm.nih.gov/pubmed/34762653
http://dx.doi.org/10.1371/journal.pgen.1009891

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