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Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia

Regulation of cytosolic calcium (Ca(2+)) dynamics is fundamental to microglial function. Temporal and spatial Ca(2+) fluxes are induced from a complicated signal transduction pathway linked to brain ionic homeostasis. In this paper, we develop a novel biophysical model of Ca(2+) and sodium (Na(+)) d...

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Detalles Bibliográficos
Autores principales:	Poshtkohi, Alireza, Wade, John, McDaid, Liam, Liu, Junxiu, Dallas, Mark, Bithell, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584768/ https://www.ncbi.nlm.nih.gov/pubmed/34723961 http://dx.doi.org/10.1371/journal.pcbi.1009520

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