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Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study

Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays a role in extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has a role in both COPD and atherogenesis. The 2011 GOLD document classified patients according to F...

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Autores principales: Nieri, Dario, Daniele, Marta, Lombardi, Stefania, Bazzan, Erica, Santerini, Sabrina, De Cusatis, Giovanna, Vagaggini, Barbara, Cosio, Manuel G., Saetta, Marina, Paggiaro, Pierluigi, Celi, Alessandro, Neri, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584816/
https://www.ncbi.nlm.nih.gov/pubmed/34768536
http://dx.doi.org/10.3390/jcm10215014
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author Nieri, Dario
Daniele, Marta
Lombardi, Stefania
Bazzan, Erica
Santerini, Sabrina
De Cusatis, Giovanna
Vagaggini, Barbara
Cosio, Manuel G.
Saetta, Marina
Paggiaro, Pierluigi
Celi, Alessandro
Neri, Tommaso
author_facet Nieri, Dario
Daniele, Marta
Lombardi, Stefania
Bazzan, Erica
Santerini, Sabrina
De Cusatis, Giovanna
Vagaggini, Barbara
Cosio, Manuel G.
Saetta, Marina
Paggiaro, Pierluigi
Celi, Alessandro
Neri, Tommaso
author_sort Nieri, Dario
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays a role in extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has a role in both COPD and atherogenesis. The 2011 GOLD document classified patients according to FEV1, symptoms, and exacerbations history, creating four groups, from A (less symptoms/low risk) to D (more symptoms/high risk). Extracellular vesicles (EV) represent potential markers in COPD: nevertheless, no studies have explored their value in association to both disease severity and inflammation. We conducted a pilot study to analyze circulating endothelial-(E) and monocyte-derived (M) EV levels in 35 COPD patients, who were grouped according to the 2011 GOLD document; the relationship between EV and plasmatic markers of inflammation was analyzed. We found a statistically significant trend for increasing EEV, MEV, IL-6, from group A to D, and a significant correlation between EEV and IL-6. The associations between both EEV and MEV and disease severity, and between EEV and IL-6, suggest a significant interplay between pulmonary disease and inflammation, with non-respiratory cells (endothelial cells and monocytes) involvement, along with the progression of the disease. Thus, EV might help identify a high-risk population for extrapulmonary events, especially in the most severe patients.
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spelling pubmed-85848162021-11-12 Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study Nieri, Dario Daniele, Marta Lombardi, Stefania Bazzan, Erica Santerini, Sabrina De Cusatis, Giovanna Vagaggini, Barbara Cosio, Manuel G. Saetta, Marina Paggiaro, Pierluigi Celi, Alessandro Neri, Tommaso J Clin Med Article Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays a role in extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has a role in both COPD and atherogenesis. The 2011 GOLD document classified patients according to FEV1, symptoms, and exacerbations history, creating four groups, from A (less symptoms/low risk) to D (more symptoms/high risk). Extracellular vesicles (EV) represent potential markers in COPD: nevertheless, no studies have explored their value in association to both disease severity and inflammation. We conducted a pilot study to analyze circulating endothelial-(E) and monocyte-derived (M) EV levels in 35 COPD patients, who were grouped according to the 2011 GOLD document; the relationship between EV and plasmatic markers of inflammation was analyzed. We found a statistically significant trend for increasing EEV, MEV, IL-6, from group A to D, and a significant correlation between EEV and IL-6. The associations between both EEV and MEV and disease severity, and between EEV and IL-6, suggest a significant interplay between pulmonary disease and inflammation, with non-respiratory cells (endothelial cells and monocytes) involvement, along with the progression of the disease. Thus, EV might help identify a high-risk population for extrapulmonary events, especially in the most severe patients. MDPI 2021-10-28 /pmc/articles/PMC8584816/ /pubmed/34768536 http://dx.doi.org/10.3390/jcm10215014 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nieri, Dario
Daniele, Marta
Lombardi, Stefania
Bazzan, Erica
Santerini, Sabrina
De Cusatis, Giovanna
Vagaggini, Barbara
Cosio, Manuel G.
Saetta, Marina
Paggiaro, Pierluigi
Celi, Alessandro
Neri, Tommaso
Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_full Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_fullStr Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_full_unstemmed Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_short Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_sort circulating extracellular vesicles are associated with disease severity and interleukin-6 levels in copd: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584816/
https://www.ncbi.nlm.nih.gov/pubmed/34768536
http://dx.doi.org/10.3390/jcm10215014
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