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Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes

Background: Microwave radiometry (MWR) assesses non-invasive carotid artery temperatures reflecting inflammation. In the present study, we aimed to investigate the impact of hypolipidemic therapy either with simvastatin or with combination simvastatin plus ezetimibe on carotid artery temperatures of...

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Autores principales: Benetos, Georgios, Galanakos, Spyros, Koutagiar, Iosif, Skoumas, Ioannis, Oikonomou, Georgios, Drakopoulou, Maria, Karmpalioti, Maria, Katsi, Vasiliki, Tsioufis, Costas, Toutouzas, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584884/
https://www.ncbi.nlm.nih.gov/pubmed/34768528
http://dx.doi.org/10.3390/jcm10215008
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author Benetos, Georgios
Galanakos, Spyros
Koutagiar, Iosif
Skoumas, Ioannis
Oikonomou, Georgios
Drakopoulou, Maria
Karmpalioti, Maria
Katsi, Vasiliki
Tsioufis, Costas
Toutouzas, Konstantinos
author_facet Benetos, Georgios
Galanakos, Spyros
Koutagiar, Iosif
Skoumas, Ioannis
Oikonomou, Georgios
Drakopoulou, Maria
Karmpalioti, Maria
Katsi, Vasiliki
Tsioufis, Costas
Toutouzas, Konstantinos
author_sort Benetos, Georgios
collection PubMed
description Background: Microwave radiometry (MWR) assesses non-invasive carotid artery temperatures reflecting inflammation. In the present study, we aimed to investigate the impact of hypolipidemic therapy either with simvastatin or with combination simvastatin plus ezetimibe on carotid artery temperatures of patients with familial hyperlipidemia syndromes (FHS). Methods: Consecutive patients with diagnosis of either familial heterozygous hypercholesterolemia (heFH) or familial combined hyperlipidemia (FCH) were included in the study. Patients were assigned to either simvastatin 40 mg or simvastatin 40 mg plus ezetimibe 10 mg, according to the discretion of the physician. FHS patients who refused statin therapy were used as a control group. Common carotid intima-media thickness (ccIMT) was measured and ΔΤ (maximum-minimum) temperature measurements were performed across each carotid during MWR evaluation. RESULTS: In total, 115 patients were included in the study. Of them, 40 patients received simvastatin (19 heFH and 21 FCH), 41 simvastatin + ezetimibe (31 heFH and 10 FCH), and 34 (21 heFH and 13 FCH) no statin. Carotid artery temperatures were significantly reduced at 6 months in FH patients who received hypolipidemic treatment (0.83 ± 0.34 versus 0.63 ± 0.24 °C, p = 0.004 for simvastatin, 1.00 ± 0.38 versus 0.69 ± 0.23 °C, p < 0.001 for simvastatin + ezetimibe), but no change was recorded in controls (0.72 ± 0.26 versus 0.70 ± 0.26 °C, p = 0.86). Conclusions: Hypolipidemic therapy reduced carotid temperatures in FHS patients.
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spelling pubmed-85848842021-11-12 Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes Benetos, Georgios Galanakos, Spyros Koutagiar, Iosif Skoumas, Ioannis Oikonomou, Georgios Drakopoulou, Maria Karmpalioti, Maria Katsi, Vasiliki Tsioufis, Costas Toutouzas, Konstantinos J Clin Med Article Background: Microwave radiometry (MWR) assesses non-invasive carotid artery temperatures reflecting inflammation. In the present study, we aimed to investigate the impact of hypolipidemic therapy either with simvastatin or with combination simvastatin plus ezetimibe on carotid artery temperatures of patients with familial hyperlipidemia syndromes (FHS). Methods: Consecutive patients with diagnosis of either familial heterozygous hypercholesterolemia (heFH) or familial combined hyperlipidemia (FCH) were included in the study. Patients were assigned to either simvastatin 40 mg or simvastatin 40 mg plus ezetimibe 10 mg, according to the discretion of the physician. FHS patients who refused statin therapy were used as a control group. Common carotid intima-media thickness (ccIMT) was measured and ΔΤ (maximum-minimum) temperature measurements were performed across each carotid during MWR evaluation. RESULTS: In total, 115 patients were included in the study. Of them, 40 patients received simvastatin (19 heFH and 21 FCH), 41 simvastatin + ezetimibe (31 heFH and 10 FCH), and 34 (21 heFH and 13 FCH) no statin. Carotid artery temperatures were significantly reduced at 6 months in FH patients who received hypolipidemic treatment (0.83 ± 0.34 versus 0.63 ± 0.24 °C, p = 0.004 for simvastatin, 1.00 ± 0.38 versus 0.69 ± 0.23 °C, p < 0.001 for simvastatin + ezetimibe), but no change was recorded in controls (0.72 ± 0.26 versus 0.70 ± 0.26 °C, p = 0.86). Conclusions: Hypolipidemic therapy reduced carotid temperatures in FHS patients. MDPI 2021-10-27 /pmc/articles/PMC8584884/ /pubmed/34768528 http://dx.doi.org/10.3390/jcm10215008 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Benetos, Georgios
Galanakos, Spyros
Koutagiar, Iosif
Skoumas, Ioannis
Oikonomou, Georgios
Drakopoulou, Maria
Karmpalioti, Maria
Katsi, Vasiliki
Tsioufis, Costas
Toutouzas, Konstantinos
Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_full Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_fullStr Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_full_unstemmed Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_short Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_sort carotid artery temperature reduction with statin therapy in patients with familial hyperlipidemia syndromes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584884/
https://www.ncbi.nlm.nih.gov/pubmed/34768528
http://dx.doi.org/10.3390/jcm10215008
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