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Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable signal sequences target roughly a quarter of the human proteome to the ER. These short peptides, mostly located at the N-termini of proteins, are highly diverse. For most proteins targeted to the ER, it is the interac...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584900/ https://www.ncbi.nlm.nih.gov/pubmed/34769302 http://dx.doi.org/10.3390/ijms222111871 |
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author | Liaci, A. Manuel Förster, Friedrich |
author_facet | Liaci, A. Manuel Förster, Friedrich |
author_sort | Liaci, A. Manuel |
collection | PubMed |
description | Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable signal sequences target roughly a quarter of the human proteome to the ER. These short peptides, mostly located at the N-termini of proteins, are highly diverse. For most proteins targeted to the ER, it is the interactions between the signal sequences and the various ER targeting and translocation machineries such as the signal recognition particle (SRP), the protein-conducting channel Sec61, and the signal peptidase complex (SPC) that determine the proteins’ target location and provide translocation fidelity. In this review, we follow the signal peptide into the ER and discuss the recent insights that structural biology has provided on the governing principles of those interactions. |
format | Online Article Text |
id | pubmed-8584900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85849002021-11-12 Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation Liaci, A. Manuel Förster, Friedrich Int J Mol Sci Review Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable signal sequences target roughly a quarter of the human proteome to the ER. These short peptides, mostly located at the N-termini of proteins, are highly diverse. For most proteins targeted to the ER, it is the interactions between the signal sequences and the various ER targeting and translocation machineries such as the signal recognition particle (SRP), the protein-conducting channel Sec61, and the signal peptidase complex (SPC) that determine the proteins’ target location and provide translocation fidelity. In this review, we follow the signal peptide into the ER and discuss the recent insights that structural biology has provided on the governing principles of those interactions. MDPI 2021-11-01 /pmc/articles/PMC8584900/ /pubmed/34769302 http://dx.doi.org/10.3390/ijms222111871 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liaci, A. Manuel Förster, Friedrich Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation |
title | Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation |
title_full | Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation |
title_fullStr | Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation |
title_full_unstemmed | Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation |
title_short | Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation |
title_sort | take me home, protein roads: structural insights into signal peptide interactions during er translocation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584900/ https://www.ncbi.nlm.nih.gov/pubmed/34769302 http://dx.doi.org/10.3390/ijms222111871 |
work_keys_str_mv | AT liaciamanuel takemehomeproteinroadsstructuralinsightsintosignalpeptideinteractionsduringertranslocation AT forsterfriedrich takemehomeproteinroadsstructuralinsightsintosignalpeptideinteractionsduringertranslocation |