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Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)

The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (...

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Autores principales: Torres-Macho, Juan, Sánchez-Fernández, Marcos, Arnanz-González, Irene, Tung-Chen, Yale, Franco-Moreno, Ana Isabel, Duffort-Falcó, Mercedes, Beltrán-Romero, Luis, Rodríguez-Suaréz, Santiago, Bernabeu-Wittel, Máximo, Urbano, Elena, Méndez-Bailon, Manuel, Roque-Rojas, Fernando, García-Guijarro, Elena, García-Casasola, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584928/
https://www.ncbi.nlm.nih.gov/pubmed/34768337
http://dx.doi.org/10.3390/jcm10214818
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author Torres-Macho, Juan
Sánchez-Fernández, Marcos
Arnanz-González, Irene
Tung-Chen, Yale
Franco-Moreno, Ana Isabel
Duffort-Falcó, Mercedes
Beltrán-Romero, Luis
Rodríguez-Suaréz, Santiago
Bernabeu-Wittel, Máximo
Urbano, Elena
Méndez-Bailon, Manuel
Roque-Rojas, Fernando
García-Guijarro, Elena
García-Casasola, Gonzalo
author_facet Torres-Macho, Juan
Sánchez-Fernández, Marcos
Arnanz-González, Irene
Tung-Chen, Yale
Franco-Moreno, Ana Isabel
Duffort-Falcó, Mercedes
Beltrán-Romero, Luis
Rodríguez-Suaréz, Santiago
Bernabeu-Wittel, Máximo
Urbano, Elena
Méndez-Bailon, Manuel
Roque-Rojas, Fernando
García-Guijarro, Elena
García-Casasola, Gonzalo
author_sort Torres-Macho, Juan
collection PubMed
description The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19.
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spelling pubmed-85849282021-11-12 Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) Torres-Macho, Juan Sánchez-Fernández, Marcos Arnanz-González, Irene Tung-Chen, Yale Franco-Moreno, Ana Isabel Duffort-Falcó, Mercedes Beltrán-Romero, Luis Rodríguez-Suaréz, Santiago Bernabeu-Wittel, Máximo Urbano, Elena Méndez-Bailon, Manuel Roque-Rojas, Fernando García-Guijarro, Elena García-Casasola, Gonzalo J Clin Med Article The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19. MDPI 2021-10-20 /pmc/articles/PMC8584928/ /pubmed/34768337 http://dx.doi.org/10.3390/jcm10214818 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torres-Macho, Juan
Sánchez-Fernández, Marcos
Arnanz-González, Irene
Tung-Chen, Yale
Franco-Moreno, Ana Isabel
Duffort-Falcó, Mercedes
Beltrán-Romero, Luis
Rodríguez-Suaréz, Santiago
Bernabeu-Wittel, Máximo
Urbano, Elena
Méndez-Bailon, Manuel
Roque-Rojas, Fernando
García-Guijarro, Elena
García-Casasola, Gonzalo
Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_full Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_fullStr Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_full_unstemmed Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_short Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_sort prediction accuracy of serial lung ultrasound in covid-19 hospitalized patients (pred-echovid study)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584928/
https://www.ncbi.nlm.nih.gov/pubmed/34768337
http://dx.doi.org/10.3390/jcm10214818
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