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Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584928/ https://www.ncbi.nlm.nih.gov/pubmed/34768337 http://dx.doi.org/10.3390/jcm10214818 |
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author | Torres-Macho, Juan Sánchez-Fernández, Marcos Arnanz-González, Irene Tung-Chen, Yale Franco-Moreno, Ana Isabel Duffort-Falcó, Mercedes Beltrán-Romero, Luis Rodríguez-Suaréz, Santiago Bernabeu-Wittel, Máximo Urbano, Elena Méndez-Bailon, Manuel Roque-Rojas, Fernando García-Guijarro, Elena García-Casasola, Gonzalo |
author_facet | Torres-Macho, Juan Sánchez-Fernández, Marcos Arnanz-González, Irene Tung-Chen, Yale Franco-Moreno, Ana Isabel Duffort-Falcó, Mercedes Beltrán-Romero, Luis Rodríguez-Suaréz, Santiago Bernabeu-Wittel, Máximo Urbano, Elena Méndez-Bailon, Manuel Roque-Rojas, Fernando García-Guijarro, Elena García-Casasola, Gonzalo |
author_sort | Torres-Macho, Juan |
collection | PubMed |
description | The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19. |
format | Online Article Text |
id | pubmed-8584928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85849282021-11-12 Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) Torres-Macho, Juan Sánchez-Fernández, Marcos Arnanz-González, Irene Tung-Chen, Yale Franco-Moreno, Ana Isabel Duffort-Falcó, Mercedes Beltrán-Romero, Luis Rodríguez-Suaréz, Santiago Bernabeu-Wittel, Máximo Urbano, Elena Méndez-Bailon, Manuel Roque-Rojas, Fernando García-Guijarro, Elena García-Casasola, Gonzalo J Clin Med Article The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19. MDPI 2021-10-20 /pmc/articles/PMC8584928/ /pubmed/34768337 http://dx.doi.org/10.3390/jcm10214818 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Torres-Macho, Juan Sánchez-Fernández, Marcos Arnanz-González, Irene Tung-Chen, Yale Franco-Moreno, Ana Isabel Duffort-Falcó, Mercedes Beltrán-Romero, Luis Rodríguez-Suaréz, Santiago Bernabeu-Wittel, Máximo Urbano, Elena Méndez-Bailon, Manuel Roque-Rojas, Fernando García-Guijarro, Elena García-Casasola, Gonzalo Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) |
title | Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) |
title_full | Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) |
title_fullStr | Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) |
title_full_unstemmed | Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) |
title_short | Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study) |
title_sort | prediction accuracy of serial lung ultrasound in covid-19 hospitalized patients (pred-echovid study) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584928/ https://www.ncbi.nlm.nih.gov/pubmed/34768337 http://dx.doi.org/10.3390/jcm10214818 |
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