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Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection

Serum albumin levels have been associated with prognosis in several conditions among older adults. The aim of this study is to assess the prognostic value in mortality of serum albumin in older adults with SARS-CoV-2 infection. Methods. Cohort observational study with consecutive older-adults (≥65 y...

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Autores principales: Arnau-Barrés, Isabel, Pascual-Dapena, Ana, López-Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Sorlí, Luisa, Herrero, Marta, Nogués, Xavier, Navarro-Valls, Claudia, Ibarra, Beatriz, Canchucaja, Lizzeth, da Costa Venancio, Elizabeth, Blasco-Hernando, Fabiola, Cruz, Juany, Vázquez, Olga, Miralles, Ramón, García-Giralt, Natalia, Güerri-Fernández, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584930/
https://www.ncbi.nlm.nih.gov/pubmed/34768653
http://dx.doi.org/10.3390/jcm10215134
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author Arnau-Barrés, Isabel
Pascual-Dapena, Ana
López-Montesinos, Inmaculada
Gómez-Zorrilla, Silvia
Sorlí, Luisa
Herrero, Marta
Nogués, Xavier
Navarro-Valls, Claudia
Ibarra, Beatriz
Canchucaja, Lizzeth
da Costa Venancio, Elizabeth
Blasco-Hernando, Fabiola
Cruz, Juany
Vázquez, Olga
Miralles, Ramón
García-Giralt, Natalia
Güerri-Fernández, Robert
author_facet Arnau-Barrés, Isabel
Pascual-Dapena, Ana
López-Montesinos, Inmaculada
Gómez-Zorrilla, Silvia
Sorlí, Luisa
Herrero, Marta
Nogués, Xavier
Navarro-Valls, Claudia
Ibarra, Beatriz
Canchucaja, Lizzeth
da Costa Venancio, Elizabeth
Blasco-Hernando, Fabiola
Cruz, Juany
Vázquez, Olga
Miralles, Ramón
García-Giralt, Natalia
Güerri-Fernández, Robert
author_sort Arnau-Barrés, Isabel
collection PubMed
description Serum albumin levels have been associated with prognosis in several conditions among older adults. The aim of this study is to assess the prognostic value in mortality of serum albumin in older adults with SARS-CoV-2 infection. Methods. Cohort observational study with consecutive older-adults (≥65 years old), with confirmed SARS-CoV-2 infection admitted to a university hospital between March–May 2020. A logistic regression model was fitted to assess the impact of albumin levels on in-hospital mortality adjusted by potential confounders. Results. Among a total of 840 patients admitted to the hospital, 405 (48%) were older adults with a total of 92 deaths (23%) among them. Those who died were older, had more comorbidities, higher inflammation status and lower levels of serum albumin at admission [3.10 g/dL (0.51) vs. 3.45 g/dL (0.45); p < 0.01. Serum albumin levels at admission were negatively correlated with inflammatory markers such as C-Reactive protein (Pearson Coeff −0.4634; p < 0.001) or IL-6 (Pearson’s Coeff −0.244; p = 0.006) at admission but also to other clinical outcomes such time to clinical stability (Pearson’s Coeff −0.259; p < 0.001). Severe hypoalbuminemia associated with increased risk of mortality was defined as ≤3 g/dL at admission according to the AUC/ROC analysis (0.72 95% CI 0.63–0.81) In a multivariate logistic regression model adjusting by age, inflammation, comorbidities and severity at admission severe hypoalbuminemia was a strong predictor of in-hospital mortality (OR 2.18 95% CI 1.03–4.62; p = 0.039). Conclusion. Severe hypoalbuminemia with ≤3 g/dL is an independent risk factor for mortality among older adults with SARS-CoV-2 infection. There is a consistent correlation between albumin levels and inflammatory biomarkers. Further studies are needed to determine whether the supplementation of albumin as coadjuvant treatment will have a positive impact on the prognosis of this infection.
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spelling pubmed-85849302021-11-12 Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection Arnau-Barrés, Isabel Pascual-Dapena, Ana López-Montesinos, Inmaculada Gómez-Zorrilla, Silvia Sorlí, Luisa Herrero, Marta Nogués, Xavier Navarro-Valls, Claudia Ibarra, Beatriz Canchucaja, Lizzeth da Costa Venancio, Elizabeth Blasco-Hernando, Fabiola Cruz, Juany Vázquez, Olga Miralles, Ramón García-Giralt, Natalia Güerri-Fernández, Robert J Clin Med Article Serum albumin levels have been associated with prognosis in several conditions among older adults. The aim of this study is to assess the prognostic value in mortality of serum albumin in older adults with SARS-CoV-2 infection. Methods. Cohort observational study with consecutive older-adults (≥65 years old), with confirmed SARS-CoV-2 infection admitted to a university hospital between March–May 2020. A logistic regression model was fitted to assess the impact of albumin levels on in-hospital mortality adjusted by potential confounders. Results. Among a total of 840 patients admitted to the hospital, 405 (48%) were older adults with a total of 92 deaths (23%) among them. Those who died were older, had more comorbidities, higher inflammation status and lower levels of serum albumin at admission [3.10 g/dL (0.51) vs. 3.45 g/dL (0.45); p < 0.01. Serum albumin levels at admission were negatively correlated with inflammatory markers such as C-Reactive protein (Pearson Coeff −0.4634; p < 0.001) or IL-6 (Pearson’s Coeff −0.244; p = 0.006) at admission but also to other clinical outcomes such time to clinical stability (Pearson’s Coeff −0.259; p < 0.001). Severe hypoalbuminemia associated with increased risk of mortality was defined as ≤3 g/dL at admission according to the AUC/ROC analysis (0.72 95% CI 0.63–0.81) In a multivariate logistic regression model adjusting by age, inflammation, comorbidities and severity at admission severe hypoalbuminemia was a strong predictor of in-hospital mortality (OR 2.18 95% CI 1.03–4.62; p = 0.039). Conclusion. Severe hypoalbuminemia with ≤3 g/dL is an independent risk factor for mortality among older adults with SARS-CoV-2 infection. There is a consistent correlation between albumin levels and inflammatory biomarkers. Further studies are needed to determine whether the supplementation of albumin as coadjuvant treatment will have a positive impact on the prognosis of this infection. MDPI 2021-10-31 /pmc/articles/PMC8584930/ /pubmed/34768653 http://dx.doi.org/10.3390/jcm10215134 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arnau-Barrés, Isabel
Pascual-Dapena, Ana
López-Montesinos, Inmaculada
Gómez-Zorrilla, Silvia
Sorlí, Luisa
Herrero, Marta
Nogués, Xavier
Navarro-Valls, Claudia
Ibarra, Beatriz
Canchucaja, Lizzeth
da Costa Venancio, Elizabeth
Blasco-Hernando, Fabiola
Cruz, Juany
Vázquez, Olga
Miralles, Ramón
García-Giralt, Natalia
Güerri-Fernández, Robert
Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection
title Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection
title_full Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection
title_fullStr Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection
title_full_unstemmed Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection
title_short Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection
title_sort severe hypoalbuminemia at admission is strongly associated with worse prognosis in older adults with sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584930/
https://www.ncbi.nlm.nih.gov/pubmed/34768653
http://dx.doi.org/10.3390/jcm10215134
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