Cargando…

Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study

Background: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition, ranging from fatty liver to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma. Recent findings suggest that patients with NAFLD have an increased risk of cardiovascular events...

Descripción completa

Detalles Bibliográficos
Autores principales: Gidaro, Antonio, Manetti, Roberto, Delitala, Alessandro Palmerio, Salvi, Emanuele, Bergamaschini, Luigi, Vidili, Gianpaolo, Castelli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585002/
https://www.ncbi.nlm.nih.gov/pubmed/34768440
http://dx.doi.org/10.3390/jcm10214906
_version_ 1784597584943251456
author Gidaro, Antonio
Manetti, Roberto
Delitala, Alessandro Palmerio
Salvi, Emanuele
Bergamaschini, Luigi
Vidili, Gianpaolo
Castelli, Roberto
author_facet Gidaro, Antonio
Manetti, Roberto
Delitala, Alessandro Palmerio
Salvi, Emanuele
Bergamaschini, Luigi
Vidili, Gianpaolo
Castelli, Roberto
author_sort Gidaro, Antonio
collection PubMed
description Background: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition, ranging from fatty liver to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma. Recent findings suggest that patients with NAFLD have an increased risk of cardiovascular events and thromboembolism, which is independent of metabolic diseases that are frequently associated with NAFLD, such as diabetes, hyperlipidemia, and obesity. Methods: We evaluated 30 NAFLD patients, before and after weight loss. Plasma levels of C-reactive protein (CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (VWF), homocysteine, coagulation protein S, Thrombin activable fibrinolysis inhibitor (TAFI), and factor VII (FVII) were assessed to evaluate whether they should be responsible of the prothrombotic state of NAFLD after weight loss. Results: At baseline, patients affected by NAFLD had a significantly higher levels of CRP, fibrinogen, PAI-1, VWF antigen, and FVII levels. After weight reduction, we observed a significant drop of inflammatory and prothrombotic markers, as well as glucometabolic, lipid profile. Conclusion: These findings provide evidence for a link between NAFLD/NASH and thromboembolism. The association seems to be linked with primitive thrombotic state and hypercoagulation due to increased levels of coagulation factors and reduced levels of PAI-1. This hypercoagulation state might explain increased levels of thrombosis and splanchnic thrombosis observed in NASH correlated cirrhosis.
format Online
Article
Text
id pubmed-8585002
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85850022021-11-12 Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study Gidaro, Antonio Manetti, Roberto Delitala, Alessandro Palmerio Salvi, Emanuele Bergamaschini, Luigi Vidili, Gianpaolo Castelli, Roberto J Clin Med Article Background: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition, ranging from fatty liver to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma. Recent findings suggest that patients with NAFLD have an increased risk of cardiovascular events and thromboembolism, which is independent of metabolic diseases that are frequently associated with NAFLD, such as diabetes, hyperlipidemia, and obesity. Methods: We evaluated 30 NAFLD patients, before and after weight loss. Plasma levels of C-reactive protein (CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (VWF), homocysteine, coagulation protein S, Thrombin activable fibrinolysis inhibitor (TAFI), and factor VII (FVII) were assessed to evaluate whether they should be responsible of the prothrombotic state of NAFLD after weight loss. Results: At baseline, patients affected by NAFLD had a significantly higher levels of CRP, fibrinogen, PAI-1, VWF antigen, and FVII levels. After weight reduction, we observed a significant drop of inflammatory and prothrombotic markers, as well as glucometabolic, lipid profile. Conclusion: These findings provide evidence for a link between NAFLD/NASH and thromboembolism. The association seems to be linked with primitive thrombotic state and hypercoagulation due to increased levels of coagulation factors and reduced levels of PAI-1. This hypercoagulation state might explain increased levels of thrombosis and splanchnic thrombosis observed in NASH correlated cirrhosis. MDPI 2021-10-25 /pmc/articles/PMC8585002/ /pubmed/34768440 http://dx.doi.org/10.3390/jcm10214906 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gidaro, Antonio
Manetti, Roberto
Delitala, Alessandro Palmerio
Salvi, Emanuele
Bergamaschini, Luigi
Vidili, Gianpaolo
Castelli, Roberto
Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_full Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_fullStr Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_full_unstemmed Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_short Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_sort prothrombotic and inflammatory markers in elderly patients with non-alcoholic hepatic liver disease before and after weight loss: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585002/
https://www.ncbi.nlm.nih.gov/pubmed/34768440
http://dx.doi.org/10.3390/jcm10214906
work_keys_str_mv AT gidaroantonio prothromboticandinflammatorymarkersinelderlypatientswithnonalcoholichepaticliverdiseasebeforeandafterweightlossapilotstudy
AT manettiroberto prothromboticandinflammatorymarkersinelderlypatientswithnonalcoholichepaticliverdiseasebeforeandafterweightlossapilotstudy
AT delitalaalessandropalmerio prothromboticandinflammatorymarkersinelderlypatientswithnonalcoholichepaticliverdiseasebeforeandafterweightlossapilotstudy
AT salviemanuele prothromboticandinflammatorymarkersinelderlypatientswithnonalcoholichepaticliverdiseasebeforeandafterweightlossapilotstudy
AT bergamaschiniluigi prothromboticandinflammatorymarkersinelderlypatientswithnonalcoholichepaticliverdiseasebeforeandafterweightlossapilotstudy
AT vidiligianpaolo prothromboticandinflammatorymarkersinelderlypatientswithnonalcoholichepaticliverdiseasebeforeandafterweightlossapilotstudy
AT castelliroberto prothromboticandinflammatorymarkersinelderlypatientswithnonalcoholichepaticliverdiseasebeforeandafterweightlossapilotstudy