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Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review

Due to their non-specific diagnostic patterns of ocular infection, differential diagnosis between Mycobacterium (M.) chimaera and tuberculosis can be challenging. In both disorders, ocular manifestation can be the first sign of a systemic infection, and a delayed diagnosis might reduce the response...

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Autores principales: Zweifel, Sandrine Anne, Foa, Nastasia, Wiest, Maximilian Robert Justus, Carnevali, Adriano, Zaluska-Ogryzek, Katarzyna, Rejdak, Robert, Toro, Mario Damiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585020/
https://www.ncbi.nlm.nih.gov/pubmed/34768406
http://dx.doi.org/10.3390/jcm10214880
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author Zweifel, Sandrine Anne
Foa, Nastasia
Wiest, Maximilian Robert Justus
Carnevali, Adriano
Zaluska-Ogryzek, Katarzyna
Rejdak, Robert
Toro, Mario Damiano
author_facet Zweifel, Sandrine Anne
Foa, Nastasia
Wiest, Maximilian Robert Justus
Carnevali, Adriano
Zaluska-Ogryzek, Katarzyna
Rejdak, Robert
Toro, Mario Damiano
author_sort Zweifel, Sandrine Anne
collection PubMed
description Due to their non-specific diagnostic patterns of ocular infection, differential diagnosis between Mycobacterium (M.) chimaera and tuberculosis can be challenging. In both disorders, ocular manifestation can be the first sign of a systemic infection, and a delayed diagnosis might reduce the response to treatment leading to negative outcomes. Thus, it becomes imperative to distinguish chorioretinal lesions associated with M. chimaera, from lesions due to M. tuberculosis and other infectious disorders. To date, multimodal non-invasive imaging modalities that include ultra-wide field fundus photography, fluorescein and indocyanine green angiography, optical coherence tomography and optical coherence tomography angiography, facilitate in vivo examination of retinal and choroidal tissues, enabling early diagnosis, monitoring treatment response, and relapse detection. This approach is crucial to differentiate between active and inactive ocular disease, and guides clinicians in their decisional-tree during the patients’ follow-up. In this review, we summarized and compared the available literature on multimodal imaging data of M. chimaera infection and tuberculosis, emphasizing similarities and differences in imaging patterns between these two entities and highlighting the relevance of multimodal imaging in the management of the infections.
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spelling pubmed-85850202021-11-12 Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review Zweifel, Sandrine Anne Foa, Nastasia Wiest, Maximilian Robert Justus Carnevali, Adriano Zaluska-Ogryzek, Katarzyna Rejdak, Robert Toro, Mario Damiano J Clin Med Review Due to their non-specific diagnostic patterns of ocular infection, differential diagnosis between Mycobacterium (M.) chimaera and tuberculosis can be challenging. In both disorders, ocular manifestation can be the first sign of a systemic infection, and a delayed diagnosis might reduce the response to treatment leading to negative outcomes. Thus, it becomes imperative to distinguish chorioretinal lesions associated with M. chimaera, from lesions due to M. tuberculosis and other infectious disorders. To date, multimodal non-invasive imaging modalities that include ultra-wide field fundus photography, fluorescein and indocyanine green angiography, optical coherence tomography and optical coherence tomography angiography, facilitate in vivo examination of retinal and choroidal tissues, enabling early diagnosis, monitoring treatment response, and relapse detection. This approach is crucial to differentiate between active and inactive ocular disease, and guides clinicians in their decisional-tree during the patients’ follow-up. In this review, we summarized and compared the available literature on multimodal imaging data of M. chimaera infection and tuberculosis, emphasizing similarities and differences in imaging patterns between these two entities and highlighting the relevance of multimodal imaging in the management of the infections. MDPI 2021-10-23 /pmc/articles/PMC8585020/ /pubmed/34768406 http://dx.doi.org/10.3390/jcm10214880 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zweifel, Sandrine Anne
Foa, Nastasia
Wiest, Maximilian Robert Justus
Carnevali, Adriano
Zaluska-Ogryzek, Katarzyna
Rejdak, Robert
Toro, Mario Damiano
Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review
title Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review
title_full Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review
title_fullStr Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review
title_full_unstemmed Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review
title_short Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review
title_sort differences between mycobacterium chimaera and tuberculosis using ocular multimodal imaging: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585020/
https://www.ncbi.nlm.nih.gov/pubmed/34768406
http://dx.doi.org/10.3390/jcm10214880
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