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Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydroph...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585031/ https://www.ncbi.nlm.nih.gov/pubmed/34771756 http://dx.doi.org/10.3390/ma14216231 |
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author | Dinis, Teresa B. V. e Silva, Francisca A. Sousa, Fani Freire, Mara G. |
author_facet | Dinis, Teresa B. V. e Silva, Francisca A. Sousa, Fani Freire, Mara G. |
author_sort | Dinis, Teresa B. V. |
collection | PubMed |
description | The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs’ aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided. |
format | Online Article Text |
id | pubmed-8585031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85850312021-11-12 Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals Dinis, Teresa B. V. e Silva, Francisca A. Sousa, Fani Freire, Mara G. Materials (Basel) Review The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs’ aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided. MDPI 2021-10-20 /pmc/articles/PMC8585031/ /pubmed/34771756 http://dx.doi.org/10.3390/ma14216231 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dinis, Teresa B. V. e Silva, Francisca A. Sousa, Fani Freire, Mara G. Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals |
title | Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals |
title_full | Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals |
title_fullStr | Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals |
title_full_unstemmed | Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals |
title_short | Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals |
title_sort | advances brought by hydrophilic ionic liquids in fields involving pharmaceuticals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585031/ https://www.ncbi.nlm.nih.gov/pubmed/34771756 http://dx.doi.org/10.3390/ma14216231 |
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