Cargando…

Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study

Several compounds based on short chain fatty acids and/or probiotics/prebiotics have shown promising results in the therapy of ulcerative colitis (UC), possibly due to its key role in restoring gut homeostasis as well as intestinal barrier integrity. Here, we investigated the efficacy of a patented...

Descripción completa

Detalles Bibliográficos
Autores principales: Caviglia, Gian Paolo, De Blasio, Federico, Vernero, Marta, Armandi, Angelo, Rosso, Chiara, Saracco, Giorgio Maria, Bugianesi, Elisabetta, Astegiano, Marco, Ribaldone, Davide Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585056/
https://www.ncbi.nlm.nih.gov/pubmed/34768480
http://dx.doi.org/10.3390/jcm10214961
_version_ 1784597598616682496
author Caviglia, Gian Paolo
De Blasio, Federico
Vernero, Marta
Armandi, Angelo
Rosso, Chiara
Saracco, Giorgio Maria
Bugianesi, Elisabetta
Astegiano, Marco
Ribaldone, Davide Giuseppe
author_facet Caviglia, Gian Paolo
De Blasio, Federico
Vernero, Marta
Armandi, Angelo
Rosso, Chiara
Saracco, Giorgio Maria
Bugianesi, Elisabetta
Astegiano, Marco
Ribaldone, Davide Giuseppe
author_sort Caviglia, Gian Paolo
collection PubMed
description Several compounds based on short chain fatty acids and/or probiotics/prebiotics have shown promising results in the therapy of ulcerative colitis (UC), possibly due to its key role in restoring gut homeostasis as well as intestinal barrier integrity. Here, we investigated the efficacy of a patented preparation based on calcium butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and fructooligosaccharides (FEEDColon(®), Princeps, Cuneo, Italy) in maintaining remission and improving subjective symptoms and inflammatory indices in patients with UC receiving 5-ASA therapy. A total of 42 patients were prospectively recruited and randomized in 21 patients receiving combination therapy with mesalamine (5-ASA) plus FEEDColon(®) and 21 patients treated with standard 5-ASA therapy. Patients were assessed at baseline, at 6-month, and 12-month follow-up (FU). Therapeutic success (defined as Mayo partial score ≤ 2 and faecal calprotectin (FC) < 250 µg/g at 12-month FU) was reached by 32 (76%) patients: 20 (95%) among those treated with 5-ASA + FeedColon(®), and 12 (57%) among those treated with 5-ASA only (p = 0.009). Consistently, patients treated with combination therapy improved subjective symptoms (quality of life, abdominal pain, and stool consistency) and reduced FC values, while those treated with 5-ASA alone, improved neither subjective symptoms nor FC during the FU. In conclusion, FEEDColon(®) supplementation appears to be a valid add-on therapy for the maintenance of remission in patients with UC. Further multicentre, placebo-controlled, double-blind clinical trials are needed to validate our results on larger cohorts of patients with UC.
format Online
Article
Text
id pubmed-8585056
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85850562021-11-12 Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study Caviglia, Gian Paolo De Blasio, Federico Vernero, Marta Armandi, Angelo Rosso, Chiara Saracco, Giorgio Maria Bugianesi, Elisabetta Astegiano, Marco Ribaldone, Davide Giuseppe J Clin Med Article Several compounds based on short chain fatty acids and/or probiotics/prebiotics have shown promising results in the therapy of ulcerative colitis (UC), possibly due to its key role in restoring gut homeostasis as well as intestinal barrier integrity. Here, we investigated the efficacy of a patented preparation based on calcium butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and fructooligosaccharides (FEEDColon(®), Princeps, Cuneo, Italy) in maintaining remission and improving subjective symptoms and inflammatory indices in patients with UC receiving 5-ASA therapy. A total of 42 patients were prospectively recruited and randomized in 21 patients receiving combination therapy with mesalamine (5-ASA) plus FEEDColon(®) and 21 patients treated with standard 5-ASA therapy. Patients were assessed at baseline, at 6-month, and 12-month follow-up (FU). Therapeutic success (defined as Mayo partial score ≤ 2 and faecal calprotectin (FC) < 250 µg/g at 12-month FU) was reached by 32 (76%) patients: 20 (95%) among those treated with 5-ASA + FeedColon(®), and 12 (57%) among those treated with 5-ASA only (p = 0.009). Consistently, patients treated with combination therapy improved subjective symptoms (quality of life, abdominal pain, and stool consistency) and reduced FC values, while those treated with 5-ASA alone, improved neither subjective symptoms nor FC during the FU. In conclusion, FEEDColon(®) supplementation appears to be a valid add-on therapy for the maintenance of remission in patients with UC. Further multicentre, placebo-controlled, double-blind clinical trials are needed to validate our results on larger cohorts of patients with UC. MDPI 2021-10-26 /pmc/articles/PMC8585056/ /pubmed/34768480 http://dx.doi.org/10.3390/jcm10214961 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caviglia, Gian Paolo
De Blasio, Federico
Vernero, Marta
Armandi, Angelo
Rosso, Chiara
Saracco, Giorgio Maria
Bugianesi, Elisabetta
Astegiano, Marco
Ribaldone, Davide Giuseppe
Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study
title Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study
title_full Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study
title_fullStr Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study
title_full_unstemmed Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study
title_short Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study
title_sort efficacy of a preparation based on calcium butyrate, bifidobacterium bifidum, bifidobacterium lactis, and fructooligosaccharides in the prevention of relapse in ulcerative colitis: a prospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585056/
https://www.ncbi.nlm.nih.gov/pubmed/34768480
http://dx.doi.org/10.3390/jcm10214961
work_keys_str_mv AT cavigliagianpaolo efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT deblasiofederico efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT verneromarta efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT armandiangelo efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT rossochiara efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT saraccogiorgiomaria efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT bugianesielisabetta efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT astegianomarco efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy
AT ribaldonedavidegiuseppe efficacyofapreparationbasedoncalciumbutyratebifidobacteriumbifidumbifidobacteriumlactisandfructooligosaccharidesinthepreventionofrelapseinulcerativecolitisaprospectiveobservationalstudy