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Serum Calretinin as a Biomarker in Malignant Mesothelioma

The early diagnosis of malignant mesothelioma (MM) could improve the prognosis of MM patients. To confirm an MM diagnosis, an immunohistochemical analysis of several tumor tissue markers, including calretinin, is currently required. Our aim is to evaluate serum calretinin as a potential biomarker in...

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Autores principales: Zupanc, Cita, Franko, Alenka, Štrbac, Danijela, Dodič Fikfak, Metoda, Kovač, Viljem, Dolžan, Vita, Goričar, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585060/
https://www.ncbi.nlm.nih.gov/pubmed/34768395
http://dx.doi.org/10.3390/jcm10214875
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author Zupanc, Cita
Franko, Alenka
Štrbac, Danijela
Dodič Fikfak, Metoda
Kovač, Viljem
Dolžan, Vita
Goričar, Katja
author_facet Zupanc, Cita
Franko, Alenka
Štrbac, Danijela
Dodič Fikfak, Metoda
Kovač, Viljem
Dolžan, Vita
Goričar, Katja
author_sort Zupanc, Cita
collection PubMed
description The early diagnosis of malignant mesothelioma (MM) could improve the prognosis of MM patients. To confirm an MM diagnosis, an immunohistochemical analysis of several tumor tissue markers, including calretinin, is currently required. Our aim is to evaluate serum calretinin as a potential biomarker in asbestos-related diseases, especially in MM. Our study includes 549 subjects: 164 MM patients, 117 subjects with asbestosis, 195 subjects with pleural plaques and 73 occupationally asbestos-exposed subjects without asbestos-related diseases. The serum calretinin concentration was determined with a commercially available enzyme immunoassay. Data on the soluble mesothelin-related peptides (SMRP) concentration are available from previous studies. MM patients had a significantly higher calretinin concentration than subjects without disease, subjects with pleural plaques or subjects with asbestosis (all p < 0.001). The histological type was significantly associated with serum calretinin: patients with sarcomatoid MM had lower calretinin than patients with the epithelioid type (p = 0.001). In a ROC curve analysis, the area under the curve for calretinin concentration predicting MM was 0.826 (95% CI = 0.782–0.869; p < 0.001). At the cutoff value of 0.32 ng/mL, sensitivity was 0.683, while specificity was 0.886. The combination of calretinin and SMRP had the highest predictive value. Calretinin is a useful biomarker that can distinguish MM from other asbestos-related diseases and could, therefore, contribute to an earlier non-invasive diagnosis of MM.
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spelling pubmed-85850602021-11-12 Serum Calretinin as a Biomarker in Malignant Mesothelioma Zupanc, Cita Franko, Alenka Štrbac, Danijela Dodič Fikfak, Metoda Kovač, Viljem Dolžan, Vita Goričar, Katja J Clin Med Article The early diagnosis of malignant mesothelioma (MM) could improve the prognosis of MM patients. To confirm an MM diagnosis, an immunohistochemical analysis of several tumor tissue markers, including calretinin, is currently required. Our aim is to evaluate serum calretinin as a potential biomarker in asbestos-related diseases, especially in MM. Our study includes 549 subjects: 164 MM patients, 117 subjects with asbestosis, 195 subjects with pleural plaques and 73 occupationally asbestos-exposed subjects without asbestos-related diseases. The serum calretinin concentration was determined with a commercially available enzyme immunoassay. Data on the soluble mesothelin-related peptides (SMRP) concentration are available from previous studies. MM patients had a significantly higher calretinin concentration than subjects without disease, subjects with pleural plaques or subjects with asbestosis (all p < 0.001). The histological type was significantly associated with serum calretinin: patients with sarcomatoid MM had lower calretinin than patients with the epithelioid type (p = 0.001). In a ROC curve analysis, the area under the curve for calretinin concentration predicting MM was 0.826 (95% CI = 0.782–0.869; p < 0.001). At the cutoff value of 0.32 ng/mL, sensitivity was 0.683, while specificity was 0.886. The combination of calretinin and SMRP had the highest predictive value. Calretinin is a useful biomarker that can distinguish MM from other asbestos-related diseases and could, therefore, contribute to an earlier non-invasive diagnosis of MM. MDPI 2021-10-22 /pmc/articles/PMC8585060/ /pubmed/34768395 http://dx.doi.org/10.3390/jcm10214875 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zupanc, Cita
Franko, Alenka
Štrbac, Danijela
Dodič Fikfak, Metoda
Kovač, Viljem
Dolžan, Vita
Goričar, Katja
Serum Calretinin as a Biomarker in Malignant Mesothelioma
title Serum Calretinin as a Biomarker in Malignant Mesothelioma
title_full Serum Calretinin as a Biomarker in Malignant Mesothelioma
title_fullStr Serum Calretinin as a Biomarker in Malignant Mesothelioma
title_full_unstemmed Serum Calretinin as a Biomarker in Malignant Mesothelioma
title_short Serum Calretinin as a Biomarker in Malignant Mesothelioma
title_sort serum calretinin as a biomarker in malignant mesothelioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585060/
https://www.ncbi.nlm.nih.gov/pubmed/34768395
http://dx.doi.org/10.3390/jcm10214875
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