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RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma

Background: Malignant glioma (MG) is an aggressive malignant brain tumor. Despite advances in multidisciplinary treatment, overall survival rates remain low. A trifluoroethyl amide derivative of 2-cyano-3-,12-dioxoolean-1,9-dien-28-oic acid (CDDO), CDDO–trifluoroethyl amide (CDDO–TFEA) is a nuclear...

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Detalles Bibliográficos
Autores principales:	Tsai, Tai-Hsin, Lieu, Ann-Shung, Huang, Tzuu-Yuan, Kwan, Aij-Lie, Lin, Chih-Lung, Hsu, Yi-Chiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585078/ https://www.ncbi.nlm.nih.gov/pubmed/34768325 http://dx.doi.org/10.3390/jcm10214805

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