New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms...

Descripción completa

Detalles Bibliográficos
Autores principales: Chausov, Denis N., Burmistrov, Dmitriy E., Kurilov, Alexander D., Bunkin, Nikolai F., Astashev, Maxim E., Simakin, Alexander V., Vedunova, Maria V., Gudkov, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585151/
https://www.ncbi.nlm.nih.gov/pubmed/34771805
http://dx.doi.org/10.3390/ma14216281
_version_ 1784597622046064640
author Chausov, Denis N.
Burmistrov, Dmitriy E.
Kurilov, Alexander D.
Bunkin, Nikolai F.
Astashev, Maxim E.
Simakin, Alexander V.
Vedunova, Maria V.
Gudkov, Sergey V.
author_facet Chausov, Denis N.
Burmistrov, Dmitriy E.
Kurilov, Alexander D.
Bunkin, Nikolai F.
Astashev, Maxim E.
Simakin, Alexander V.
Vedunova, Maria V.
Gudkov, Sergey V.
author_sort Chausov, Denis N.
collection PubMed
description The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.
format Online
Article
Text
id pubmed-8585151
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85851512021-11-12 New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells Chausov, Denis N. Burmistrov, Dmitriy E. Kurilov, Alexander D. Bunkin, Nikolai F. Astashev, Maxim E. Simakin, Alexander V. Vedunova, Maria V. Gudkov, Sergey V. Materials (Basel) Article The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained. MDPI 2021-10-21 /pmc/articles/PMC8585151/ /pubmed/34771805 http://dx.doi.org/10.3390/ma14216281 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chausov, Denis N.
Burmistrov, Dmitriy E.
Kurilov, Alexander D.
Bunkin, Nikolai F.
Astashev, Maxim E.
Simakin, Alexander V.
Vedunova, Maria V.
Gudkov, Sergey V.
New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_full New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_fullStr New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_full_unstemmed New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_short New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_sort new organosilicon composite based on borosiloxane and zinc oxide nanoparticles inhibits bacterial growth, but does not have a toxic effect on the development of animal eukaryotic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585151/
https://www.ncbi.nlm.nih.gov/pubmed/34771805
http://dx.doi.org/10.3390/ma14216281
work_keys_str_mv AT chausovdenisn neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells
AT burmistrovdmitriye neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells
AT kurilovalexanderd neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells
AT bunkinnikolaif neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells
AT astashevmaxime neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells
AT simakinalexanderv neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells
AT vedunovamariav neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells
AT gudkovsergeyv neworganosiliconcompositebasedonborosiloxaneandzincoxidenanoparticlesinhibitsbacterialgrowthbutdoesnothaveatoxiceffectonthedevelopmentofanimaleukaryoticcells

Ejemplares similares