Cargando…

The Novel Positive Allosteric Modulator of the GABA(B) Receptor, KK-92A, Suppresses Alcohol Self-Administration and Cue-Induced Reinstatement of Alcohol Seeking in Rats

Positive allosteric modulators (PAMs) of the GABA(B) receptor (GABA(B) PAMs) are of interest in the addiction field due to their ability to suppress several behaviors motivated by drugs of abuse. KK-92A is a novel GABA(B) PAM found to attenuate intravenous self-administration of nicotine and reinsta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maccioni, Paola, Kaczanowska, Katarzyna, Lawrence, Harshani, Yun, Sang, Bratzu, Jessica, Gessa, Gian Luigi, McDonald, Patricia, Colombo, Giancarlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585307/ https://www.ncbi.nlm.nih.gov/pubmed/34778249 http://dx.doi.org/10.3389/fcell.2021.727576

Ejemplares similares

A Phaseolus vulgaris Extract Reduces Cue-Induced Reinstatement of Chocolate Seeking in Rats
por: Lorrai, Irene, et al.
Publicado: (2016)

Reduction by the Positive Allosteric Modulator of the GABA(B) Receptor, GS39783, of Alcohol Self-Administration in Sardinian Alcohol-Preferring Rats Exposed to the “Sipper” Procedure
por: Maccioni, Paola, et al.
Publicado: (2010)

Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking
por: Weiland, Ana, et al.
Publicado: (2015)

R(+)-Baclofen, but Not S(−)-Baclofen, Alters Alcohol Self-Administration in Alcohol-Preferring Rats
por: Lorrai, Irene, et al.
Publicado: (2016)

7,8-Dihydroxyflavone Enhances Cue-Conditioned Alcohol Reinstatement in Rats
por: Hogarth, Samuel J., et al.
Publicado: (2020)

Suppressing Effect of Baclofen on Multiple Alcohol-Related Behaviors in Laboratory Animals
por: Colombo, Giancarlo, et al.
Publicado: (2018)

The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in rats
por: Funk, Douglas, et al.
Publicado: (2014)

Effects of the Alpha-1 Antagonist Prazosin on KOR Agonist-Induced Reinstatement of Alcohol Seeking
por: Funk, Douglas, et al.
Publicado: (2019)

Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/− mice
por: Cabana-Domínguez, Judit, et al.
Publicado: (2021)

Oxytocin Attenuates the Stress-Induced Reinstatement of Alcohol-Seeking in Male Rats: Role of the Central Amygdala
por: Ballas, Hannah S., et al.
Publicado: (2021)

Oxytocin Attenuates Yohimbine-Induced Reinstatement of Alcohol-Seeking in Female Rats via the Central Amygdala
por: Wilfur, Samantha M., et al.
Publicado: (2023)

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking
por: Wilkinson, Courtney S., et al.
Publicado: (2023)

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking
por: Wilkinson, Courtney S., et al.
Publicado: (2023)

Optogenetic dissection of basolateral amygdala projections during cue-induced reinstatement of cocaine seeking
por: Stefanik, Michael T., et al.
Publicado: (2013)

AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking
por: Gao, Xue-Jiao, et al.
Publicado: (2017)

GABA(B) receptor allosteric modulators exhibit pathway‐dependent and species‐selective activity
por: Sturchler, Emmanuel, et al.
Publicado: (2017)

Suppression by γ-Hydroxybutyric Acid of “Alcohol Deprivation Effect” in Rats: Preclinical Evidence of its anti-Relapse Properties
por: Colombo, Giancarlo, et al.
Publicado: (2012)

The α7nACh–NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking
por: Li, Shupeng, et al.
Publicado: (2012)

Author Correction: AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking
por: Gao, Xue-Jiao, et al.
Publicado: (2020)

Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats
por: Gancarz, Amy M., et al.
Publicado: (2023)

Repeated administration of the GABA(B) receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats
por: Vlachou, Styliani, et al.
Publicado: (2010)

Deletion of the GABA(A) α2-subunit does not alter self administration of cocaine or reinstatement of cocaine seeking
por: Dixon, C. I., et al.
Publicado: (2014)

GABA(B) receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence
por: Agabio, Roberta, et al.
Publicado: (2014)

An amylin analogue attenuates alcohol-related behaviours in various animal models of alcohol use disorder
por: Kalafateli, Aimilia Lydia, et al.
Publicado: (2019)

A persistent alcohol cue memory trace drives relapse to alcohol seeking after prolonged abstinence
por: Visser, Esther, et al.
Publicado: (2020)

Effect of Cafeteria Diet History on Cue-, Pellet-Priming-, and Stress-Induced Reinstatement of Food Seeking in Female Rats
por: Chen, Yu-Wei, et al.
Publicado: (2014)

Lack of Increased Immediate Early Gene Expression in Rats Reinstating Cocaine-Seeking Behavior to Discrete Sensory Cues
por: Riedy, Matthew D., et al.
Publicado: (2013)

Recent Advances in the Potential of Positive Allosteric Modulators of the GABA(B) Receptor to Treat Alcohol Use Disorder
por: Augier, Eric
Publicado: (2021)

Pavlovian-conditioned alcohol-seeking behavior in rats is invigorated by the interaction between discrete and contextual alcohol cues: implications for relapse
por: Remedios, Jessica, et al.
Publicado: (2014)

Differential Effects of Dorsal and Ventral Medial Prefrontal Cortex Inactivation during Natural Reward Seeking, Extinction, and Cue-Induced Reinstatement
por: Caballero, Jessica P., et al.
Publicado: (2019)

Activation of the GABA(B) Receptor Prevents Nicotine-Induced Locomotor Stimulation in Mice
por: Lobina, Carla, et al.
Publicado: (2011)

Dopamine D1 receptor blockade impairs alcohol seeking without reducing dorsal striatal activation to cues of alcohol availability
por: Fanelli, Rebecca R, et al.
Publicado: (2015)

New Neurons in the Dentate Gyrus Promote Reinstatement of Methamphetamine Seeking
por: Mandyam, Chitra D, et al.
Publicado: (2018)

Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients
por: Alarefi, Abdulqawi, et al.
Publicado: (2022)

Inactivation of the Nucleus Accumbens Core or Medial Shell Attenuates Reinstatement of Sugar-Seeking Behavior following Sugar Priming or Exposure to Food-Associated Cues
por: Lin, Peagan, et al.
Publicado: (2014)

Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control
por: Wouda, Jelte A., et al.
Publicado: (2011)

The Inhibition of Histone Deacetylases Reduces the Reinstatement of Cocaine-Seeking Behavior in Rats
por: Romieu, Pascal, et al.
Publicado: (2011)

Inactivation of the Prelimbic Cortex Impairs the Context-Induced Reinstatement of Ethanol Seeking
por: Palombo, Paola, et al.
Publicado: (2017)

Gender Differences among Sardinians with Alcohol Use Disorder
por: Agabio, Roberta, et al.
Publicado: (2021)

Study of a ($KK\pi$) enhancement in $KK3\pi$ annihilations
por: Armenteros, R, et al.
Publicado: (1966)

Cannot write session to /tmp/vufind_sessions/sess_jai9dmok2s3pl06fc8mnd2i9el