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The Novel Positive Allosteric Modulator of the GABA(B) Receptor, KK-92A, Suppresses Alcohol Self-Administration and Cue-Induced Reinstatement of Alcohol Seeking in Rats
Positive allosteric modulators (PAMs) of the GABA(B) receptor (GABA(B) PAMs) are of interest in the addiction field due to their ability to suppress several behaviors motivated by drugs of abuse. KK-92A is a novel GABA(B) PAM found to attenuate intravenous self-administration of nicotine and reinsta...
Autores principales: | Maccioni, Paola, Kaczanowska, Katarzyna, Lawrence, Harshani, Yun, Sang, Bratzu, Jessica, Gessa, Gian Luigi, McDonald, Patricia, Colombo, Giancarlo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585307/ https://www.ncbi.nlm.nih.gov/pubmed/34778249 http://dx.doi.org/10.3389/fcell.2021.727576 |
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