Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength

How T cell receptor (TCR) signal strength modulates T cell function and to what extent this is modified by immune checkpoint blockade (ICB) are key questions in immunology. Using Nr4a3-Tocky mice, we characterized early quantitative and qualitative changes that occur in CD4(+) T cells in relation to...

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Detalles Bibliográficos
Autores principales: Elliot, Thomas A.E., Jennings, Emma K., Lecky, David A.J., Thawait, Natasha, Flores-Langarica, Adriana, Copland, Alastair, Maslowski, Kendle M., Wraith, David C., Bending, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585507/
https://www.ncbi.nlm.nih.gov/pubmed/34534438
http://dx.doi.org/10.1016/j.immuni.2021.08.020

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