Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

Early prenatal inflammatory conditions are thought to be a risk factor for different neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy causes abnormal behavior in offspring, but whether these defects result from altered synaptic developmental trajectories remains...

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Detalles Bibliográficos
Autores principales: Mirabella, Filippo, Desiato, Genni, Mancinelli, Sara, Fossati, Giuliana, Rasile, Marco, Morini, Raffaella, Markicevic, Marija, Grimm, Christina, Amegandjin, Clara, Termanini, Alberto, Peano, Clelia, Kunderfranco, Paolo, di Cristo, Graziella, Zerbi, Valerio, Menna, Elisabetta, Lodato, Simona, Matteoli, Michela, Pozzi, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585508/
https://www.ncbi.nlm.nih.gov/pubmed/34758338
http://dx.doi.org/10.1016/j.immuni.2021.10.006

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