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Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic()
The COVID-19 pandemic has revealed a ventilator deficit in the global health system for this scenario. For this reason, several national and international projects have been developed to get done prototypes of ventilators which could be easy and fast to manufacture. One of the requirements of the AE...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585596/ https://www.ncbi.nlm.nih.gov/pubmed/34802971 http://dx.doi.org/10.1016/j.redare.2020.10.008 |
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author | Viscasillas, J. Alonso-Iñigo, J.M. Gutierrez-Bautista, A. Casañ Pallardó, M. Redondo, J.I. |
author_facet | Viscasillas, J. Alonso-Iñigo, J.M. Gutierrez-Bautista, A. Casañ Pallardó, M. Redondo, J.I. |
author_sort | Viscasillas, J. |
collection | PubMed |
description | The COVID-19 pandemic has revealed a ventilator deficit in the global health system for this scenario. For this reason, several national and international projects have been developed to get done prototypes of ventilators which could be easy and fast to manufacture. One of the requirements of the AEMPS for conducting clinical studies with new prototypes is through the validation of these new prototypes in an animal model. Therefore, it is important to achieve an animal model which allows us to easily reproduce different clinical scenarios. In this article, we describe the use of a sheep as a research model to assess a prototype ventilator. The animal was anesthetized for 10 h in which the prototype was tested in up to 6 different scenarios. This model is effective and easy to reproduce, making it an excellent choice for this kind of research. |
format | Online Article Text |
id | pubmed-8585596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85855962021-11-12 Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic() Viscasillas, J. Alonso-Iñigo, J.M. Gutierrez-Bautista, A. Casañ Pallardó, M. Redondo, J.I. Rev Esp Anestesiol Reanim (Engl Ed) Case Report The COVID-19 pandemic has revealed a ventilator deficit in the global health system for this scenario. For this reason, several national and international projects have been developed to get done prototypes of ventilators which could be easy and fast to manufacture. One of the requirements of the AEMPS for conducting clinical studies with new prototypes is through the validation of these new prototypes in an animal model. Therefore, it is important to achieve an animal model which allows us to easily reproduce different clinical scenarios. In this article, we describe the use of a sheep as a research model to assess a prototype ventilator. The animal was anesthetized for 10 h in which the prototype was tested in up to 6 different scenarios. This model is effective and easy to reproduce, making it an excellent choice for this kind of research. Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. 2021-12 2021-11-12 /pmc/articles/PMC8585596/ /pubmed/34802971 http://dx.doi.org/10.1016/j.redare.2020.10.008 Text en © 2020 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Case Report Viscasillas, J. Alonso-Iñigo, J.M. Gutierrez-Bautista, A. Casañ Pallardó, M. Redondo, J.I. Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic() |
title | Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic() |
title_full | Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic() |
title_fullStr | Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic() |
title_full_unstemmed | Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic() |
title_short | Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic() |
title_sort | description of ovine model for testing ventilator prototypes in the covid-19 pandemic() |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585596/ https://www.ncbi.nlm.nih.gov/pubmed/34802971 http://dx.doi.org/10.1016/j.redare.2020.10.008 |
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