Cargando…

Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study

Purpose: This study aimed to determine the longitudinal association between hand grip strength (HGS) and the development of non-alcoholic fatty liver disease (NAFLD) in adults. Design: A cohort study. Methods: This study was conducted in a general Chinese population (n = 14,154) from 2013–2018. NAFL...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Yang, Cao, Limin, Liu, Yashu, Wang, Xuena, Zhang, Shunming, Meng, Ge, Zhang, Qing, Liu, Li, Wu, Hongmei, Gu, Yeqing, Wang, Yawen, Zhang, Tingjing, Wang, Xing, Sun, Shaomei, Zhou, Ming, Jia, Qiyu, Song, Kun, Niu, Kaijun, Zhao, Yuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585737/
https://www.ncbi.nlm.nih.gov/pubmed/34778314
http://dx.doi.org/10.3389/fmed.2021.752999
_version_ 1784597743865430016
author Xia, Yang
Cao, Limin
Liu, Yashu
Wang, Xuena
Zhang, Shunming
Meng, Ge
Zhang, Qing
Liu, Li
Wu, Hongmei
Gu, Yeqing
Wang, Yawen
Zhang, Tingjing
Wang, Xing
Sun, Shaomei
Zhou, Ming
Jia, Qiyu
Song, Kun
Niu, Kaijun
Zhao, Yuhong
author_facet Xia, Yang
Cao, Limin
Liu, Yashu
Wang, Xuena
Zhang, Shunming
Meng, Ge
Zhang, Qing
Liu, Li
Wu, Hongmei
Gu, Yeqing
Wang, Yawen
Zhang, Tingjing
Wang, Xing
Sun, Shaomei
Zhou, Ming
Jia, Qiyu
Song, Kun
Niu, Kaijun
Zhao, Yuhong
author_sort Xia, Yang
collection PubMed
description Purpose: This study aimed to determine the longitudinal association between hand grip strength (HGS) and the development of non-alcoholic fatty liver disease (NAFLD) in adults. Design: A cohort study. Methods: This study was conducted in a general Chinese population (n = 14,154) from 2013–2018. NAFLD was diagnosed by liver ultrasonography during evaluating alcohol consumption. The associations between the HGS and NAFLD were assessed using a multivariable Cox proportional hazards regression model. Results: During the study period with a mean follow-up duration of 3.20 years, 2,452 participants developed NAFLD. The risk of NAFLD decreased progressively with increasing HGS in both men and women (P for trend <0.0001). The multivariate-adjusted hazard ratios (95% CI) for NAFLD incidence across the quartiles of HGS were 1 (reference), 0.90 (0.79, 1.02), 0.69 (0.60, 0.79), and 0.44 (0.37, 0.52) for men and 1 (reference), 0.82 (0.69, 0.96), 0.54 (0.45, 0.66), and 0.41 (0.33, 0.52) for women, respectively. The interaction terms for body mass index (BMI)-HGS and waist-HGS were significant in men and women (all P < 0.0001). The participants with normal BMIs and waist circumferences had the lowest hazard ratios on the subgroup analyses. The sensitivity analysis that defined NAFLD using the hepatic steatosis and fatty liver indices revealed results that were similar to the main analyses. Conclusion: The present study indicates that the HGS is inversely associated with the incidence of NAFLD.
format Online
Article
Text
id pubmed-8585737
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85857372021-11-13 Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study Xia, Yang Cao, Limin Liu, Yashu Wang, Xuena Zhang, Shunming Meng, Ge Zhang, Qing Liu, Li Wu, Hongmei Gu, Yeqing Wang, Yawen Zhang, Tingjing Wang, Xing Sun, Shaomei Zhou, Ming Jia, Qiyu Song, Kun Niu, Kaijun Zhao, Yuhong Front Med (Lausanne) Medicine Purpose: This study aimed to determine the longitudinal association between hand grip strength (HGS) and the development of non-alcoholic fatty liver disease (NAFLD) in adults. Design: A cohort study. Methods: This study was conducted in a general Chinese population (n = 14,154) from 2013–2018. NAFLD was diagnosed by liver ultrasonography during evaluating alcohol consumption. The associations between the HGS and NAFLD were assessed using a multivariable Cox proportional hazards regression model. Results: During the study period with a mean follow-up duration of 3.20 years, 2,452 participants developed NAFLD. The risk of NAFLD decreased progressively with increasing HGS in both men and women (P for trend <0.0001). The multivariate-adjusted hazard ratios (95% CI) for NAFLD incidence across the quartiles of HGS were 1 (reference), 0.90 (0.79, 1.02), 0.69 (0.60, 0.79), and 0.44 (0.37, 0.52) for men and 1 (reference), 0.82 (0.69, 0.96), 0.54 (0.45, 0.66), and 0.41 (0.33, 0.52) for women, respectively. The interaction terms for body mass index (BMI)-HGS and waist-HGS were significant in men and women (all P < 0.0001). The participants with normal BMIs and waist circumferences had the lowest hazard ratios on the subgroup analyses. The sensitivity analysis that defined NAFLD using the hepatic steatosis and fatty liver indices revealed results that were similar to the main analyses. Conclusion: The present study indicates that the HGS is inversely associated with the incidence of NAFLD. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8585737/ /pubmed/34778314 http://dx.doi.org/10.3389/fmed.2021.752999 Text en Copyright © 2021 Xia, Cao, Liu, Wang, Zhang, Meng, Zhang, Liu, Wu, Gu, Wang, Zhang, Wang, Sun, Zhou, Jia, Song, Niu and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Xia, Yang
Cao, Limin
Liu, Yashu
Wang, Xuena
Zhang, Shunming
Meng, Ge
Zhang, Qing
Liu, Li
Wu, Hongmei
Gu, Yeqing
Wang, Yawen
Zhang, Tingjing
Wang, Xing
Sun, Shaomei
Zhou, Ming
Jia, Qiyu
Song, Kun
Niu, Kaijun
Zhao, Yuhong
Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study
title Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study
title_full Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study
title_fullStr Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study
title_full_unstemmed Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study
title_short Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study
title_sort longitudinal associations between hand grip strength and non-alcoholic fatty liver disease in adults: a prospective cohort study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585737/
https://www.ncbi.nlm.nih.gov/pubmed/34778314
http://dx.doi.org/10.3389/fmed.2021.752999
work_keys_str_mv AT xiayang longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT caolimin longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT liuyashu longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT wangxuena longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT zhangshunming longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT mengge longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT zhangqing longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT liuli longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT wuhongmei longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT guyeqing longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT wangyawen longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT zhangtingjing longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT wangxing longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT sunshaomei longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT zhouming longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT jiaqiyu longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT songkun longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT niukaijun longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy
AT zhaoyuhong longitudinalassociationsbetweenhandgripstrengthandnonalcoholicfattyliverdiseaseinadultsaprospectivecohortstudy