Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain Injury

Mild traumatic brain injury (TBI) involves widespread axonal injury and activation of microglia, which initiates secondary processes that worsen the TBI outcome. The upregulation of cannabinoid type-2 receptors (CB2) when microglia become activated allows CB2-binding drugs to selectively target micr...

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Detalles Bibliográficos
Autores principales: Honig, Marcia G., Del Mar, Nobel A., Henderson, Desmond L., O’Neal, Dylan, Doty, John B., Cox, Rachel, Li, Chunyan, Perry, Aaron M., Moore, Bob M., Reiner, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585747/
https://www.ncbi.nlm.nih.gov/pubmed/34776838
http://dx.doi.org/10.3389/fnins.2021.701317

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