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A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study
We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of futur...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585790/ https://www.ncbi.nlm.nih.gov/pubmed/34777479 http://dx.doi.org/10.3389/fgene.2021.763159 |
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| author | Marjonen, Heidi Marttila, Minttu Paajanen, Teemu Vornanen, Marleena Brunfeldt, Minna Joensuu, Anni Halmesvaara, Otto Aro, Kimmo Alanne-Kinnunen, Mervi Jousilahti, Pekka Borodulin, Katja Koskinen, Seppo Tuomi, Tiinamaija Ilanne-Parikka, Pirjo Lindström, Jaana Laine, Merja K. Auro, Kirsi Kääriäinen, Helena Perola, Markus Kristiansson, Kati |
| author_facet | Marjonen, Heidi Marttila, Minttu Paajanen, Teemu Vornanen, Marleena Brunfeldt, Minna Joensuu, Anni Halmesvaara, Otto Aro, Kimmo Alanne-Kinnunen, Mervi Jousilahti, Pekka Borodulin, Katja Koskinen, Seppo Tuomi, Tiinamaija Ilanne-Parikka, Pirjo Lindström, Jaana Laine, Merja K. Auro, Kirsi Kääriäinen, Helena Perola, Markus Kristiansson, Kati |
| author_sort | Marjonen, Heidi |
| collection | PubMed |
| description | We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care. |
| format | Online Article Text |
| id | pubmed-8585790 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85857902021-11-13 A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study Marjonen, Heidi Marttila, Minttu Paajanen, Teemu Vornanen, Marleena Brunfeldt, Minna Joensuu, Anni Halmesvaara, Otto Aro, Kimmo Alanne-Kinnunen, Mervi Jousilahti, Pekka Borodulin, Katja Koskinen, Seppo Tuomi, Tiinamaija Ilanne-Parikka, Pirjo Lindström, Jaana Laine, Merja K. Auro, Kirsi Kääriäinen, Helena Perola, Markus Kristiansson, Kati Front Genet Genetics We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8585790/ /pubmed/34777479 http://dx.doi.org/10.3389/fgene.2021.763159 Text en Copyright © 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindström, Laine, Auro, Kääriäinen, Perola and Kristiansson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Genetics Marjonen, Heidi Marttila, Minttu Paajanen, Teemu Vornanen, Marleena Brunfeldt, Minna Joensuu, Anni Halmesvaara, Otto Aro, Kimmo Alanne-Kinnunen, Mervi Jousilahti, Pekka Borodulin, Katja Koskinen, Seppo Tuomi, Tiinamaija Ilanne-Parikka, Pirjo Lindström, Jaana Laine, Merja K. Auro, Kirsi Kääriäinen, Helena Perola, Markus Kristiansson, Kati A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study |
| title | A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study |
| title_full | A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study |
| title_fullStr | A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study |
| title_full_unstemmed | A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study |
| title_short | A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study |
| title_sort | web portal for communicating polygenic risk score results for health care use—the p5 study |
| topic | Genetics |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585790/ https://www.ncbi.nlm.nih.gov/pubmed/34777479 http://dx.doi.org/10.3389/fgene.2021.763159 |
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