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Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering

The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature chondrocytes. To provide viable treatment options, tremendous efforts have been...

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Detalles Bibliográficos
Autores principales: Zhu, Mingjing, Zhong, Wenchao, Cao, Wei, Zhang, Qingbin, Wu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585793/
https://www.ncbi.nlm.nih.gov/pubmed/34820567
http://dx.doi.org/10.1016/j.bioactmat.2021.07.004
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author Zhu, Mingjing
Zhong, Wenchao
Cao, Wei
Zhang, Qingbin
Wu, Gang
author_facet Zhu, Mingjing
Zhong, Wenchao
Cao, Wei
Zhang, Qingbin
Wu, Gang
author_sort Zhu, Mingjing
collection PubMed
description The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature chondrocytes. To provide viable treatment options, tremendous efforts have been made to develop various chondrogenically-functionalized biomaterials for cartilage tissue engineering. Peptides that are derived from and mimic the functions of chondroconductive cartilage extracellular matrix and chondroinductive growth factors, represent a unique group of bioactive agents for chondrogenic functionalization. Since they can be chemically synthesized, peptides bear better reproducibility, more stable efficacy, higher modifiability and yielding efficiency in comparison with naturally derived biomaterials and recombinant growth factors. In this review, we summarize the current knowledge in the designs of the chondroinductive/chondroconductive peptides, the underlying molecular mechanisms and their-functionalized biomaterials for cartilage tissue engineering. We also systematically compare their in-vitro and in-vivo efficacies in inducing chondrogenesis. Our vision is to stimulate the development of novel peptides and their-functionalized biomaterials for cartilage tissue engineering.
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spelling pubmed-85857932021-11-23 Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering Zhu, Mingjing Zhong, Wenchao Cao, Wei Zhang, Qingbin Wu, Gang Bioact Mater Article The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature chondrocytes. To provide viable treatment options, tremendous efforts have been made to develop various chondrogenically-functionalized biomaterials for cartilage tissue engineering. Peptides that are derived from and mimic the functions of chondroconductive cartilage extracellular matrix and chondroinductive growth factors, represent a unique group of bioactive agents for chondrogenic functionalization. Since they can be chemically synthesized, peptides bear better reproducibility, more stable efficacy, higher modifiability and yielding efficiency in comparison with naturally derived biomaterials and recombinant growth factors. In this review, we summarize the current knowledge in the designs of the chondroinductive/chondroconductive peptides, the underlying molecular mechanisms and their-functionalized biomaterials for cartilage tissue engineering. We also systematically compare their in-vitro and in-vivo efficacies in inducing chondrogenesis. Our vision is to stimulate the development of novel peptides and their-functionalized biomaterials for cartilage tissue engineering. KeAi Publishing 2021-07-14 /pmc/articles/PMC8585793/ /pubmed/34820567 http://dx.doi.org/10.1016/j.bioactmat.2021.07.004 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhu, Mingjing
Zhong, Wenchao
Cao, Wei
Zhang, Qingbin
Wu, Gang
Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
title Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
title_full Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
title_fullStr Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
title_full_unstemmed Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
title_short Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
title_sort chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585793/
https://www.ncbi.nlm.nih.gov/pubmed/34820567
http://dx.doi.org/10.1016/j.bioactmat.2021.07.004
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