The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers

PURPOSE: Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation. METHODS: We analysed samples from three pharmacokinetic studies to determine the serum concentrations of naloxone-3-glucuronide...

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Detalles Bibliográficos
Autores principales: Tylleskar, Ida, Skarra, Sissel, Skulberg, Arne Kristian, Dale, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585821/
https://www.ncbi.nlm.nih.gov/pubmed/34327552
http://dx.doi.org/10.1007/s00228-021-03190-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585821/
https://www.ncbi.nlm.nih.gov/pubmed/34327552
http://dx.doi.org/10.1007/s00228-021-03190-1

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