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Tau in the Pathophysiology of Parkinson’s Disease
The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs) in remaining neurons. LBs primarily consist of aggregated α-Synuclein (α-Syn). However, accumulating evidence suggests that Tau,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585831/ https://www.ncbi.nlm.nih.gov/pubmed/33459970 http://dx.doi.org/10.1007/s12031-020-01776-5 |
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author | Pan, Lina Meng, Lanxia He, Mingyang Zhang, Zhentao |
author_facet | Pan, Lina Meng, Lanxia He, Mingyang Zhang, Zhentao |
author_sort | Pan, Lina |
collection | PubMed |
description | The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs) in remaining neurons. LBs primarily consist of aggregated α-Synuclein (α-Syn). However, accumulating evidence suggests that Tau, which is associated with tauopathies such as Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), and argyrophilic grain disease, is also involved in the pathophysiology of PD. A genome-wide association study (GWAS) identified MAPT, the gene encoding the Tau protein, as a risk gene for PD. Autopsy of PD patients also revealed the colocalization of Tau and α-Syn in LBs. Experimental evidence has shown that Tau interacts with α-Syn and influences the pathology of α-Syn in PD. In this review, we discuss the structure and function of Tau and provide a summary of the current evidence supporting Tau’s involvement as either an active or passive element in the pathophysiology of PD, which may provide novel targets for the early diagnosis and treatment of PD. |
format | Online Article Text |
id | pubmed-8585831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-85858312021-11-15 Tau in the Pathophysiology of Parkinson’s Disease Pan, Lina Meng, Lanxia He, Mingyang Zhang, Zhentao J Mol Neurosci Article The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs) in remaining neurons. LBs primarily consist of aggregated α-Synuclein (α-Syn). However, accumulating evidence suggests that Tau, which is associated with tauopathies such as Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), and argyrophilic grain disease, is also involved in the pathophysiology of PD. A genome-wide association study (GWAS) identified MAPT, the gene encoding the Tau protein, as a risk gene for PD. Autopsy of PD patients also revealed the colocalization of Tau and α-Syn in LBs. Experimental evidence has shown that Tau interacts with α-Syn and influences the pathology of α-Syn in PD. In this review, we discuss the structure and function of Tau and provide a summary of the current evidence supporting Tau’s involvement as either an active or passive element in the pathophysiology of PD, which may provide novel targets for the early diagnosis and treatment of PD. Springer US 2021-01-18 2021 /pmc/articles/PMC8585831/ /pubmed/33459970 http://dx.doi.org/10.1007/s12031-020-01776-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Pan, Lina Meng, Lanxia He, Mingyang Zhang, Zhentao Tau in the Pathophysiology of Parkinson’s Disease |
title | Tau in the Pathophysiology of Parkinson’s Disease |
title_full | Tau in the Pathophysiology of Parkinson’s Disease |
title_fullStr | Tau in the Pathophysiology of Parkinson’s Disease |
title_full_unstemmed | Tau in the Pathophysiology of Parkinson’s Disease |
title_short | Tau in the Pathophysiology of Parkinson’s Disease |
title_sort | tau in the pathophysiology of parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585831/ https://www.ncbi.nlm.nih.gov/pubmed/33459970 http://dx.doi.org/10.1007/s12031-020-01776-5 |
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