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Metabolomic credentialing of murine carcinogen-induced urothelial cancer
Bladder cancer (BCa) is the most common malignancy of the urinary system with increasing incidence, mortality, and limited treatment options. Therefore, it is imperative to validate preclinical models that faithfully represent BCa cellular, molecular, and metabolic heterogeneity to develop new thera...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585868/ https://www.ncbi.nlm.nih.gov/pubmed/34764423 http://dx.doi.org/10.1038/s41598-021-99746-3 |
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author | Afify, Hesham Ghoneum, Alia Almousa, Sameh Abdulfattah, Ammar Yasser Warren, Bailey Langsten, Kendall Gonzalez, Daniela Casals, Randy Bharadwaj, Manish Kridel, Steven Said, Neveen |
author_facet | Afify, Hesham Ghoneum, Alia Almousa, Sameh Abdulfattah, Ammar Yasser Warren, Bailey Langsten, Kendall Gonzalez, Daniela Casals, Randy Bharadwaj, Manish Kridel, Steven Said, Neveen |
author_sort | Afify, Hesham |
collection | PubMed |
description | Bladder cancer (BCa) is the most common malignancy of the urinary system with increasing incidence, mortality, and limited treatment options. Therefore, it is imperative to validate preclinical models that faithfully represent BCa cellular, molecular, and metabolic heterogeneity to develop new therapeutics. We performed metabolomic profiling of premalignant and non-muscle invasive bladder cancer (NMIBC) that ensued in the chemical carcinogenesis N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model. We identified the enriched metabolic signatures that associate with premalignant and NMIBC. We found that enrichment of lipid metabolism is the forerunner of carcinogen-induced premalignant and NMIBC lesions. Cross-species analysis revealed the prognostic value of the enzymes associated with carcinogen-induced enriched metabolic in human disease. To date, this is the first study describing the global metabolomic profiles associated with early premalignant and NMIBC and provide evidence that these metabolomic signatures can be used for prognostication of human disease. |
format | Online Article Text |
id | pubmed-8585868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85858682021-11-12 Metabolomic credentialing of murine carcinogen-induced urothelial cancer Afify, Hesham Ghoneum, Alia Almousa, Sameh Abdulfattah, Ammar Yasser Warren, Bailey Langsten, Kendall Gonzalez, Daniela Casals, Randy Bharadwaj, Manish Kridel, Steven Said, Neveen Sci Rep Article Bladder cancer (BCa) is the most common malignancy of the urinary system with increasing incidence, mortality, and limited treatment options. Therefore, it is imperative to validate preclinical models that faithfully represent BCa cellular, molecular, and metabolic heterogeneity to develop new therapeutics. We performed metabolomic profiling of premalignant and non-muscle invasive bladder cancer (NMIBC) that ensued in the chemical carcinogenesis N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model. We identified the enriched metabolic signatures that associate with premalignant and NMIBC. We found that enrichment of lipid metabolism is the forerunner of carcinogen-induced premalignant and NMIBC lesions. Cross-species analysis revealed the prognostic value of the enzymes associated with carcinogen-induced enriched metabolic in human disease. To date, this is the first study describing the global metabolomic profiles associated with early premalignant and NMIBC and provide evidence that these metabolomic signatures can be used for prognostication of human disease. Nature Publishing Group UK 2021-11-11 /pmc/articles/PMC8585868/ /pubmed/34764423 http://dx.doi.org/10.1038/s41598-021-99746-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Afify, Hesham Ghoneum, Alia Almousa, Sameh Abdulfattah, Ammar Yasser Warren, Bailey Langsten, Kendall Gonzalez, Daniela Casals, Randy Bharadwaj, Manish Kridel, Steven Said, Neveen Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
title | Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
title_full | Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
title_fullStr | Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
title_full_unstemmed | Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
title_short | Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
title_sort | metabolomic credentialing of murine carcinogen-induced urothelial cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585868/ https://www.ncbi.nlm.nih.gov/pubmed/34764423 http://dx.doi.org/10.1038/s41598-021-99746-3 |
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