The first observation of osmotically neutral sodium accumulation in the myocardial interstitium

The aim of this study was the detection and quantification of the Na(+) depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluore...

Descripción completa

Detalles Bibliográficos
Autores principales: Artyukov, I., Arutyunov, G., Bobrov, M., Bukreeva, I., Cedola, A., Dragunov, D., Feshchenko, R., Fratini, M., Mitrokhin, V., Sokolova, A., Vinogradov, A., Gianoncelli, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585917/
https://www.ncbi.nlm.nih.gov/pubmed/34764351
http://dx.doi.org/10.1038/s41598-021-01443-8
_version_ 1784597786027622400
author Artyukov, I.
Arutyunov, G.
Bobrov, M.
Bukreeva, I.
Cedola, A.
Dragunov, D.
Feshchenko, R.
Fratini, M.
Mitrokhin, V.
Sokolova, A.
Vinogradov, A.
Gianoncelli, A.
author_facet Artyukov, I.
Arutyunov, G.
Bobrov, M.
Bukreeva, I.
Cedola, A.
Dragunov, D.
Feshchenko, R.
Fratini, M.
Mitrokhin, V.
Sokolova, A.
Vinogradov, A.
Gianoncelli, A.
author_sort Artyukov, I.
collection PubMed
description The aim of this study was the detection and quantification of the Na(+) depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluorescence (XRF) spectromicroscopy technique used to perform a comparative analysis of sodium containment in intracellular and interstitial spaces of cardiac tissues taken from animals selected by low and high sodium intake rates. The experimental results obtained show that high sodium daily intake can result in a remarkable increase of sodium content in the myocardial interstitium.
format Online
Article
Text
id pubmed-8585917
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-85859172021-11-12 The first observation of osmotically neutral sodium accumulation in the myocardial interstitium Artyukov, I. Arutyunov, G. Bobrov, M. Bukreeva, I. Cedola, A. Dragunov, D. Feshchenko, R. Fratini, M. Mitrokhin, V. Sokolova, A. Vinogradov, A. Gianoncelli, A. Sci Rep Article The aim of this study was the detection and quantification of the Na(+) depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluorescence (XRF) spectromicroscopy technique used to perform a comparative analysis of sodium containment in intracellular and interstitial spaces of cardiac tissues taken from animals selected by low and high sodium intake rates. The experimental results obtained show that high sodium daily intake can result in a remarkable increase of sodium content in the myocardial interstitium. Nature Publishing Group UK 2021-11-11 /pmc/articles/PMC8585917/ /pubmed/34764351 http://dx.doi.org/10.1038/s41598-021-01443-8 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Artyukov, I.
Arutyunov, G.
Bobrov, M.
Bukreeva, I.
Cedola, A.
Dragunov, D.
Feshchenko, R.
Fratini, M.
Mitrokhin, V.
Sokolova, A.
Vinogradov, A.
Gianoncelli, A.
The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
title The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
title_full The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
title_fullStr The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
title_full_unstemmed The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
title_short The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
title_sort first observation of osmotically neutral sodium accumulation in the myocardial interstitium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585917/
https://www.ncbi.nlm.nih.gov/pubmed/34764351
http://dx.doi.org/10.1038/s41598-021-01443-8
work_keys_str_mv AT artyukovi thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT arutyunovg thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT bobrovm thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT bukreevai thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT cedolaa thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT dragunovd thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT feshchenkor thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT fratinim thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT mitrokhinv thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT sokolovaa thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT vinogradova thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT gianoncellia thefirstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT artyukovi firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT arutyunovg firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT bobrovm firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT bukreevai firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT cedolaa firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT dragunovd firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT feshchenkor firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT fratinim firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT mitrokhinv firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT sokolovaa firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT vinogradova firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium
AT gianoncellia firstobservationofosmoticallyneutralsodiumaccumulationinthemyocardialinterstitium

Ejemplares similares