Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis

Bony fusion caused by pathological new bone formation manifests the clinical feature of ankylosing spondylitis (AS). However, the underlying mechanism remains elusive. Here we discovered spontaneous kyphosis, arthritis and bony fusion in mature CD4-Cre;Ptpn11(f/f) mice, which present the pathophysio...

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Detalles Bibliográficos
Autores principales: Shao, Fenli, Liu, Qianqian, Zhu, Yuyu, Fan, Zhidan, Chen, Wenjun, Liu, Shijia, Li, Xiaohui, Guo, Wenjie, Feng, Gen-Sheng, Yu, Haiguo, Xu, Qiang, Sun, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585952/
https://www.ncbi.nlm.nih.gov/pubmed/34764263
http://dx.doi.org/10.1038/s41467-021-26750-6

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