ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway

J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken. It has been demonstrated that interferon-stimulated genes (ISGs) could limit ALV-J replication; nevertheless, the underlying mechanisms remain obscure....

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Autores principales: Zhang, Qihong, Xie, Tingting, Mo, Guodong, Zhang, Zihao, Lin, Ling, Zhang, Xiquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585972/
https://www.ncbi.nlm.nih.gov/pubmed/34777393
http://dx.doi.org/10.3389/fimmu.2021.774323
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author Zhang, Qihong
Xie, Tingting
Mo, Guodong
Zhang, Zihao
Lin, Ling
Zhang, Xiquan
author_facet Zhang, Qihong
Xie, Tingting
Mo, Guodong
Zhang, Zihao
Lin, Ling
Zhang, Xiquan
author_sort Zhang, Qihong
collection PubMed
description J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken. It has been demonstrated that interferon-stimulated genes (ISGs) could limit ALV-J replication; nevertheless, the underlying mechanisms remain obscure. Here, we demonstrate that Long-chain Acyl-CoA synthetase 1 (ACSL1) is an interferon (IFN)-stimulated gene that specifically restricts the replication of ALV-J due to the higher IFN-I production. More importantly, ACSL1 induces primary monocyte-derived macrophages (MDMs) to pro-inflammatory phenotypic states during ALV-J infection, and ACSL1 mediates apoptosis through the PI3K/Akt signaling pathway in ALV-J-infected primary monocyte-derived macrophages (MDMs). Overall, these results provide evidence that ACSL1 contributes to the antiviral response against ALV-J.
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spelling pubmed-85859722021-11-13 ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway Zhang, Qihong Xie, Tingting Mo, Guodong Zhang, Zihao Lin, Ling Zhang, Xiquan Front Immunol Immunology J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken. It has been demonstrated that interferon-stimulated genes (ISGs) could limit ALV-J replication; nevertheless, the underlying mechanisms remain obscure. Here, we demonstrate that Long-chain Acyl-CoA synthetase 1 (ACSL1) is an interferon (IFN)-stimulated gene that specifically restricts the replication of ALV-J due to the higher IFN-I production. More importantly, ACSL1 induces primary monocyte-derived macrophages (MDMs) to pro-inflammatory phenotypic states during ALV-J infection, and ACSL1 mediates apoptosis through the PI3K/Akt signaling pathway in ALV-J-infected primary monocyte-derived macrophages (MDMs). Overall, these results provide evidence that ACSL1 contributes to the antiviral response against ALV-J. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8585972/ /pubmed/34777393 http://dx.doi.org/10.3389/fimmu.2021.774323 Text en Copyright © 2021 Zhang, Xie, Mo, Zhang, Lin and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Qihong
Xie, Tingting
Mo, Guodong
Zhang, Zihao
Lin, Ling
Zhang, Xiquan
ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
title ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
title_full ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
title_fullStr ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
title_full_unstemmed ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
title_short ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
title_sort acsl1 inhibits alv-j replication by ifn-ⅰ signaling and pi3k/akt pathway
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585972/
https://www.ncbi.nlm.nih.gov/pubmed/34777393
http://dx.doi.org/10.3389/fimmu.2021.774323
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