ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization

Super-enhancers (SEs) govern macrophage polarization and function. However, the mechanism underlying the signal-dependent latent SEs remodeling in macrophages remains largely undefined. Here we show that the epigenetic reader ZMYND8 forms liquid compartments with NF-κB/p65 to silence latent SEs and...

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Detalles Bibliográficos
Autores principales: Jia, Pan, Li, Xiang, Wang, Xuelei, Yao, Liangjiao, Xu, Yingying, Hu, Yu, Xu, Wenwen, He, Zhe, Zhao, Qifan, Deng, Yicong, Zang, Yi, Zhang, Meiyu, Zhang, Yan, Qin, Jun, Lu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586003/
https://www.ncbi.nlm.nih.gov/pubmed/34764296
http://dx.doi.org/10.1038/s41467-021-26864-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586003/
https://www.ncbi.nlm.nih.gov/pubmed/34764296
http://dx.doi.org/10.1038/s41467-021-26864-x

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