Insulin-activated store-operated Ca(2+) entry via Orai1 induces podocyte actin remodeling and causes proteinuria

Podocyte, the gatekeeper of the glomerular filtration barrier, is a primary target for growth factor and Ca(2+) signaling whose perturbation leads to proteinuria. However, the effects of insulin action on store-operated Ca(2+) entry (SOCE) in podocytes remain unknown. Here, we demonstrated that insu...

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Detalles Bibliográficos
Autores principales: Kim, Ji-Hee, Hwang, Kyu-Hee, Dang, Bao T. N., Eom, Minseob, Kong, In Deok, Gwack, Yousang, Yu, Seyoung, Gee, Heon Yung, Birnbaumer, Lutz, Park, Kyu-Sang, Cha, Seung-Kuy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586150/
https://www.ncbi.nlm.nih.gov/pubmed/34764278
http://dx.doi.org/10.1038/s41467-021-26900-w

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