Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, and find focal amplifications in the GCA cohort are associated with the chromothripsis proce...

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Detalles Bibliográficos
Autores principales: Zhao, Xue-Ke, Xing, Pengwei, Song, Xin, Zhao, Miao, Zhao, Linxuan, Dang, Yonglong, Lei, Ling-Ling, Xu, Rui-Hua, Han, Wen-Li, Wang, Pan-Pan, Yang, Miao-Miao, Hu, Jing-Feng, Zhong, Kan, Zhou, Fu-You, Han, Xue-Na, Meng, Chao-Long, Ji, Jia-Jia, Chen, Xingqi, Wang, Li-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586158/
https://www.ncbi.nlm.nih.gov/pubmed/34764264
http://dx.doi.org/10.1038/s41467-021-26745-3

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