Cargando…

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, cerebral atrophy, and severe psychomotor impairment. The phenotype is similar to congenital cytomegalovirus brain infection and overlaps with type I interferonopathies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kettwig, Matthias, Ternka, Katharina, Wendland, Kristin, Krüger, Dennis Manfred, Zampar, Silvia, Schob, Charlotte, Franz, Jonas, Aich, Abhishek, Winkler, Anne, Sakib, M. Sadman, Kaurani, Lalit, Epple, Robert, Werner, Hauke B., Hakroush, Samy, Kitz, Julia, Prinz, Marco, Bartok, Eva, Hartmann, Gunther, Schröder, Simone, Rehling, Peter, Henneke, Marco, Boretius, Susann, Alia, A., Wirths, Oliver, Fischer, Andre, Stadelmann, Christine, Nessler, Stefan, Gärtner, Jutta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586222/ https://www.ncbi.nlm.nih.gov/pubmed/34764281 http://dx.doi.org/10.1038/s41467-021-26880-x

Ejemplares similares

The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2‐deficient leukoencephalopathy
por: Hamilton, Noémie, et al.
Publicado: (2020)

Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia
por: Weber, Thomas, et al.
Publicado: (2020)

RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory
por: Sinkevicius, Kerstin W., et al.
Publicado: (2018)

Chromosome 6 encoded RNaseT2 protein is a cell growth regulator
por: Liu, Jinglan, et al.
Publicado: (2010)

Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase
por: Lualdi, Marta, et al.
Publicado: (2015)

Human recombinant truncated RNASET2, devoid of RNase activity; A potential cancer therapeutic agent
por: Nesiel-Nuttman, Liron, et al.
Publicado: (2014)

A Pre- and Co-Knockdown of RNAseT Enzyme, Eri-1, Enhances the Efficiency of RNAi Induced Gene Silencing in Caenorhabditis elegans
por: Jadiya, Pooja, et al.
Publicado: (2014)

RNASET2-deficient leukoencephalopathy mimicking congenital CMV infection and Aicardi-Goutieres syndrome: a case report with a novel pathogenic variant
por: Kameli, Reyhaneh, et al.
Publicado: (2019)

Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models
por: Wirths, Oliver, et al.
Publicado: (2020)

Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau
por: Zampar, Silvia, et al.
Publicado: (2021)

Innate Immune Response Regulation by the Human RNASET2 Tumor Suppressor Gene
por: Acquati, Francesco, et al.
Publicado: (2019)

Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells
por: Acquati, Francesco, et al.
Publicado: (2011)

Human recombinant RNASET2: A potential anti-cancer drug
por: Roiz, Levava, et al.
Publicado: (2016)

Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2
por: Liu, Peipei, et al.
Publicado: (2017)

Compound heterozygous variants in PGAP1 causing severe psychomotor retardation, brain atrophy, recurrent apneas and delayed myelination: a case report and literature review
por: Kettwig, Matthias, et al.
Publicado: (2016)

Modular architecture of eukaryotic RNase P and RNase MRP revealed by electron microscopy
por: Hipp, Katharina, et al.
Publicado: (2012)

Molecular characterization and immune modulation properties of Clonorchis sinensis-derived RNASET2
por: Xu, Yanquan, et al.
Publicado: (2013)

Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma
por: Zeng, Zhi, et al.
Publicado: (2020)

Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis
por: Stazi, Martina, et al.
Publicado: (2021)

Diagnostic and therapeutic potential of RNASET2 in Crohn’s disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion
por: Biener-Ramanujan, Eva, et al.
Publicado: (2022)

Late-onset leukoencephalopathy with cerebral calcifications and cysts: case report and review of the literature
por: Stephani, C., et al.
Publicado: (2016)

HTLV-1 Tax directly modulates expression of the CDK6 and RNASET2 genes
por: Polakowski, Nicholas, et al.
Publicado: (2011)

Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2)
por: Huang, Jinliang, et al.
Publicado: (2018)

FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer
por: Ji, Mei, et al.
Publicado: (2021)

3D Reconstruction of HvRNASET2 Molecule to Understand Its Antibacterial Role
por: Baranzini, Nicolò, et al.
Publicado: (2020)

Conserved reduction of m(6)A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts
por: Castro-Hernández, Ricardo, et al.
Publicado: (2023)

Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer’s Disease
por: Gerberding, Anna-Lina, et al.
Publicado: (2019)

A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model
por: Stazi, Martina, et al.
Publicado: (2023)

Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
por: Stazi, Martina, et al.
Publicado: (2022)

Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro
por: Wang, Q, et al.
Publicado: (2014)

Human RNASET2 derivatives as potential anti-angiogenic agents: actin binding sequence identification and characterization
por: Nesiel-Nuttman, Liron, et al.
Publicado: (2014)

A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling
por: Roggiani, Francesca, et al.
Publicado: (2019)

Antimicrobial Role of RNASET2 Protein During Innate Immune Response in the Medicinal Leech Hirudo verbana
por: Baranzini, Nicolò, et al.
Publicado: (2020)

HvRNASET2 Regulate Connective Tissue and Collagen I Remodeling During Wound Healing Process
por: Baranzini, Nicolò, et al.
Publicado: (2021)

RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population
por: Chen, Xiao-jun, et al.
Publicado: (2015)

Structure and mechanistic features of the prokaryotic minimal RNase P
por: Feyh, Rebecca, et al.
Publicado: (2021)

Three-dimensional testicular organoids as novel in vitro models of testicular biology and toxicology
por: Sakib, Sadman, et al.
Publicado: (2019)

Magnetic CuFe(2)O(4) Nanoparticles with Pseudocapacitive Properties for Electrical Energy Storage
por: Liang, Wenyu, et al.
Publicado: (2022)

Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma
por: Liu, Yifu, et al.
Publicado: (2023)

Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway
por: Monaci, Sara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h7aoq7g1lq42ov1ddia3p8epbv