Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

CRISPR knockout fitness screens in cancer cell lines reveal many genes whose loss of function causes cell death or loss of fitness or, more rarely, the opposite phenotype of faster proliferation. Here we demonstrate a systematic approach to identify these proliferation suppressors, which are highly...

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Detalles Bibliográficos
Autores principales: Lenoir, W. Frank, Morgado, Micaela, DeWeirdt, Peter C., McLaughlin, Megan, Griffith, Audrey L., Sangree, Annabel K., Feeley, Marissa N., Esmaeili Anvar, Nazanin, Kim, Eiru, Bertolet, Lori L., Colic, Medina, Dede, Merve, Doench, John G., Hart, Traver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586352/
https://www.ncbi.nlm.nih.gov/pubmed/34764293
http://dx.doi.org/10.1038/s41467-021-26867-8

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