Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

Cellular heterogeneity is a major cause of treatment resistance in cancer. Despite recent advances in single-cell genomic and transcriptomic sequencing, it remains difficult to relate measured molecular profiles to the cellular activities underlying cancer. Here, we present an integrated experimenta...

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Detalles Bibliográficos
Autores principales: Contreras-Trujillo, Humberto, Eerdeng, Jiya, Akre, Samir, Jiang, Du, Contreras, Jorge, Gala, Basia, Vergel-Rodriguez, Mary C., Lee, Yeachan, Jorapur, Aparna, Andreasian, Areen, Harton, Lisa, Bramlett, Charles S., Nogalska, Anna, Xiao, Gang, Lee, Jae-Woong, Chan, Lai N., Müschen, Markus, Merchant, Akil A., Lu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586369/
https://www.ncbi.nlm.nih.gov/pubmed/34764253
http://dx.doi.org/10.1038/s41467-021-26771-1

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