Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration

Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism of extracellular matrix, and the cytosolic dsDNA accumulation and STING–NF–κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc (IVD) degeneration....

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Detalles Bibliográficos
Autores principales: Chen, Jiaxin, Zhu, Haifeng, Zhu, Yutao, Zhao, Chenchen, Wang, Shengyu, Zheng, Yixin, Xie, Ziang, Jin, Yang, Song, Honghai, Yang, Linjun, Zhang, Jin, Dai, Jiayong, Hu, Zhijun, Wang, Huaiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586437/
https://www.ncbi.nlm.nih.gov/pubmed/34820553
http://dx.doi.org/10.1016/j.bioactmat.2021.08.003

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