Cargando…

Is There a Histone Code for Cellular Quiescence?

Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair and maintenance, quiescent cells receive the appropriate stimulus and are induced to enter the cell cycle. The ability of cells to successfully transi...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonitto, Kenya, Sarathy, Kirthana, Atai, Kaiser, Mitra, Mithun, Coller, Hilary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586460/
https://www.ncbi.nlm.nih.gov/pubmed/34778253
http://dx.doi.org/10.3389/fcell.2021.739780
_version_ 1784597892932042752
author Bonitto, Kenya
Sarathy, Kirthana
Atai, Kaiser
Mitra, Mithun
Coller, Hilary A.
author_facet Bonitto, Kenya
Sarathy, Kirthana
Atai, Kaiser
Mitra, Mithun
Coller, Hilary A.
author_sort Bonitto, Kenya
collection PubMed
description Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair and maintenance, quiescent cells receive the appropriate stimulus and are induced to enter the cell cycle. The ability of cells to successfully transition into and out of a quiescent state is crucial for many biological processes including wound healing, stem cell maintenance, and immunological responses. Across species and tissues, transcriptional, epigenetic, and chromosomal changes associated with the transition between proliferation and quiescence have been analyzed, and some consistent changes associated with quiescence have been identified. Histone modifications have been shown to play a role in chromatin packing and accessibility, nucleosome mobility, gene expression, and chromosome arrangement. In this review, we critically evaluate the role of different histone marks in these processes during quiescence entry and exit. We consider different model systems for quiescence, each of the most frequently monitored candidate histone marks, and the role of their writers, erasers and readers. We highlight data that support these marks contributing to the changes observed with quiescence. We specifically ask whether there is a quiescence histone “code,” a mechanism whereby the language encoded by specific combinations of histone marks is read and relayed downstream to modulate cell state and function. We conclude by highlighting emerging technologies that can be applied to gain greater insight into the role of a histone code for quiescence.
format Online
Article
Text
id pubmed-8586460
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85864602021-11-13 Is There a Histone Code for Cellular Quiescence? Bonitto, Kenya Sarathy, Kirthana Atai, Kaiser Mitra, Mithun Coller, Hilary A. Front Cell Dev Biol Cell and Developmental Biology Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair and maintenance, quiescent cells receive the appropriate stimulus and are induced to enter the cell cycle. The ability of cells to successfully transition into and out of a quiescent state is crucial for many biological processes including wound healing, stem cell maintenance, and immunological responses. Across species and tissues, transcriptional, epigenetic, and chromosomal changes associated with the transition between proliferation and quiescence have been analyzed, and some consistent changes associated with quiescence have been identified. Histone modifications have been shown to play a role in chromatin packing and accessibility, nucleosome mobility, gene expression, and chromosome arrangement. In this review, we critically evaluate the role of different histone marks in these processes during quiescence entry and exit. We consider different model systems for quiescence, each of the most frequently monitored candidate histone marks, and the role of their writers, erasers and readers. We highlight data that support these marks contributing to the changes observed with quiescence. We specifically ask whether there is a quiescence histone “code,” a mechanism whereby the language encoded by specific combinations of histone marks is read and relayed downstream to modulate cell state and function. We conclude by highlighting emerging technologies that can be applied to gain greater insight into the role of a histone code for quiescence. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8586460/ /pubmed/34778253 http://dx.doi.org/10.3389/fcell.2021.739780 Text en Copyright © 2021 Bonitto, Sarathy, Atai, Mitra and Coller. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Bonitto, Kenya
Sarathy, Kirthana
Atai, Kaiser
Mitra, Mithun
Coller, Hilary A.
Is There a Histone Code for Cellular Quiescence?
title Is There a Histone Code for Cellular Quiescence?
title_full Is There a Histone Code for Cellular Quiescence?
title_fullStr Is There a Histone Code for Cellular Quiescence?
title_full_unstemmed Is There a Histone Code for Cellular Quiescence?
title_short Is There a Histone Code for Cellular Quiescence?
title_sort is there a histone code for cellular quiescence?
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586460/
https://www.ncbi.nlm.nih.gov/pubmed/34778253
http://dx.doi.org/10.3389/fcell.2021.739780
work_keys_str_mv AT bonittokenya isthereahistonecodeforcellularquiescence
AT sarathykirthana isthereahistonecodeforcellularquiescence
AT ataikaiser isthereahistonecodeforcellularquiescence
AT mitramithun isthereahistonecodeforcellularquiescence
AT collerhilarya isthereahistonecodeforcellularquiescence