Cargando…
HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance
Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a mother can accept a genetically distinct fetus without immunological aggressive behavior. HLA-G, one of the non-classical HLA class I molecules, is restricted-expression at extravillous trophoblast. It can conc...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586502/ https://www.ncbi.nlm.nih.gov/pubmed/34777357 http://dx.doi.org/10.3389/fimmu.2021.744324 |
_version_ | 1784597897497542656 |
---|---|
author | Zhuang, Baimei Shang, Jin Yao, Yuanqing |
author_facet | Zhuang, Baimei Shang, Jin Yao, Yuanqing |
author_sort | Zhuang, Baimei |
collection | PubMed |
description | Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a mother can accept a genetically distinct fetus without immunological aggressive behavior. HLA-G, one of the non-classical HLA class I molecules, is restricted-expression at extravillous trophoblast. It can concordantly interact with various kinds of receptors mounted on maternally immune cells residing in the uterus (e.g. CD4+ T cells, CD8+ T cells, natural killer cells, macrophages, and dendritic cells) for maintaining immune homeostasis of the maternal-fetus interface. HLA-G is widely regarded as the pivotal protective factor for successful pregnancies. In the past 20 years, researches associated with HLA-G have been continually published. Indeed, HLA-G plays a mysterious role in the mechanism of maternal-fetal immune-tolerance. It can also be ectopically expressed on tumor cells, infected sites and other pathologic microenvironments to confer a significant local tolerance. Understanding the characteristics of HLA-G in immunologic tolerance is not only beneficial for pathological pregnancy, but also helpful to the therapy of other immune-related diseases, such as organ transplant rejection, tumor migration, and autoimmune disease. In this review, we describe the biological properties of HLA-G, then summarize our understanding of the mechanisms of fetomaternal immunologic tolerance and the difference from transplant tolerance. Furthermore, we will discuss how HLA-G contributes to the tolerogenic microenvironment during pregnancy. Finally, we hope to find some new aspects of HLA-G in fundamental research or clinical application for the future. |
format | Online Article Text |
id | pubmed-8586502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85865022021-11-13 HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance Zhuang, Baimei Shang, Jin Yao, Yuanqing Front Immunol Immunology Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a mother can accept a genetically distinct fetus without immunological aggressive behavior. HLA-G, one of the non-classical HLA class I molecules, is restricted-expression at extravillous trophoblast. It can concordantly interact with various kinds of receptors mounted on maternally immune cells residing in the uterus (e.g. CD4+ T cells, CD8+ T cells, natural killer cells, macrophages, and dendritic cells) for maintaining immune homeostasis of the maternal-fetus interface. HLA-G is widely regarded as the pivotal protective factor for successful pregnancies. In the past 20 years, researches associated with HLA-G have been continually published. Indeed, HLA-G plays a mysterious role in the mechanism of maternal-fetal immune-tolerance. It can also be ectopically expressed on tumor cells, infected sites and other pathologic microenvironments to confer a significant local tolerance. Understanding the characteristics of HLA-G in immunologic tolerance is not only beneficial for pathological pregnancy, but also helpful to the therapy of other immune-related diseases, such as organ transplant rejection, tumor migration, and autoimmune disease. In this review, we describe the biological properties of HLA-G, then summarize our understanding of the mechanisms of fetomaternal immunologic tolerance and the difference from transplant tolerance. Furthermore, we will discuss how HLA-G contributes to the tolerogenic microenvironment during pregnancy. Finally, we hope to find some new aspects of HLA-G in fundamental research or clinical application for the future. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8586502/ /pubmed/34777357 http://dx.doi.org/10.3389/fimmu.2021.744324 Text en Copyright © 2021 Zhuang, Shang and Yao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhuang, Baimei Shang, Jin Yao, Yuanqing HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance |
title | HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance |
title_full | HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance |
title_fullStr | HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance |
title_full_unstemmed | HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance |
title_short | HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance |
title_sort | hla-g: an important mediator of maternal-fetal immune-tolerance |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586502/ https://www.ncbi.nlm.nih.gov/pubmed/34777357 http://dx.doi.org/10.3389/fimmu.2021.744324 |
work_keys_str_mv | AT zhuangbaimei hlaganimportantmediatorofmaternalfetalimmunetolerance AT shangjin hlaganimportantmediatorofmaternalfetalimmunetolerance AT yaoyuanqing hlaganimportantmediatorofmaternalfetalimmunetolerance |