Cargando…
Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study
Purpose: The aim of the study was to evaluate the cost-effectiveness of PEGylated recombinant human granulocyte–stimulating factor (PEG-rhG-CSF) as a means of achieving primary and secondary prophylaxis against chemotherapy-induced neutropenia cancer cases. Methods: Individuals who underwent PEG-rhG...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586644/ https://www.ncbi.nlm.nih.gov/pubmed/34776940 http://dx.doi.org/10.3389/fphar.2021.690874 |
_version_ | 1784597933034831872 |
---|---|
author | Wu, Qiuji Li, Qiu Zhang, Jun Luo, Zhumei Zhou, Jin Chen, Jing Luo, Yong |
author_facet | Wu, Qiuji Li, Qiu Zhang, Jun Luo, Zhumei Zhou, Jin Chen, Jing Luo, Yong |
author_sort | Wu, Qiuji |
collection | PubMed |
description | Purpose: The aim of the study was to evaluate the cost-effectiveness of PEGylated recombinant human granulocyte–stimulating factor (PEG-rhG-CSF) as a means of achieving primary and secondary prophylaxis against chemotherapy-induced neutropenia cancer cases. Methods: Individuals who underwent PEG-rhG-CSF therapeutics were monitored for 12 months, together with thorough examination of individual medical records for extracting medical care costs. Both prophylaxis-based therapeutic options (primary/secondary) were scrutinized for cost-effectiveness, using a decision-making analysis model which derived the perspective of Chinese payers. One-way and probabilistic sensitivity analyses were used to assess the robustness of the model. Results: In summary, 130 clinical cases treated using PEG-rhG-CSF prophylaxis were included in this study: 51 within the primary prophylaxis (PP) group and 79 within the secondary prophylaxis (SP) group. Compared with SP, PP-based PEG-rhG-CSF successfully contributed to a 14.3% reduction in febrile neutropenia. In general, PP was estimated to reduce costs by $4,701.81 in comparison to SP, with a gain of 0.02 quality-adjusted life years (QALYs). Equivalent results were found in differing febrile neutropenia (FN) risk subgroups. Sensitivity analyses found the model outputs to be most affected for the average time of hospitalization and for the cost of FN. Conclusion: From the perspective of Chinese payers, PP with PEG-rhG-CSF should be considered cost-effective compared to SP strategies in patients who received chemotherapy regimens with a middle- to high-risk of FN. |
format | Online Article Text |
id | pubmed-8586644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85866442021-11-13 Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study Wu, Qiuji Li, Qiu Zhang, Jun Luo, Zhumei Zhou, Jin Chen, Jing Luo, Yong Front Pharmacol Pharmacology Purpose: The aim of the study was to evaluate the cost-effectiveness of PEGylated recombinant human granulocyte–stimulating factor (PEG-rhG-CSF) as a means of achieving primary and secondary prophylaxis against chemotherapy-induced neutropenia cancer cases. Methods: Individuals who underwent PEG-rhG-CSF therapeutics were monitored for 12 months, together with thorough examination of individual medical records for extracting medical care costs. Both prophylaxis-based therapeutic options (primary/secondary) were scrutinized for cost-effectiveness, using a decision-making analysis model which derived the perspective of Chinese payers. One-way and probabilistic sensitivity analyses were used to assess the robustness of the model. Results: In summary, 130 clinical cases treated using PEG-rhG-CSF prophylaxis were included in this study: 51 within the primary prophylaxis (PP) group and 79 within the secondary prophylaxis (SP) group. Compared with SP, PP-based PEG-rhG-CSF successfully contributed to a 14.3% reduction in febrile neutropenia. In general, PP was estimated to reduce costs by $4,701.81 in comparison to SP, with a gain of 0.02 quality-adjusted life years (QALYs). Equivalent results were found in differing febrile neutropenia (FN) risk subgroups. Sensitivity analyses found the model outputs to be most affected for the average time of hospitalization and for the cost of FN. Conclusion: From the perspective of Chinese payers, PP with PEG-rhG-CSF should be considered cost-effective compared to SP strategies in patients who received chemotherapy regimens with a middle- to high-risk of FN. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8586644/ /pubmed/34776940 http://dx.doi.org/10.3389/fphar.2021.690874 Text en Copyright © 2021 Wu, Li, Zhang, Luo, Zhou, Chen and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Wu, Qiuji Li, Qiu Zhang, Jun Luo, Zhumei Zhou, Jin Chen, Jing Luo, Yong Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study |
title | Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study |
title_full | Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study |
title_fullStr | Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study |
title_full_unstemmed | Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study |
title_short | Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study |
title_sort | comparison of primary and secondary prophylaxis using pegylated recombinant human granulocyte–stimulating factor as a cost-effective measure in malignant neoplasms: a multicenter retrospective study |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586644/ https://www.ncbi.nlm.nih.gov/pubmed/34776940 http://dx.doi.org/10.3389/fphar.2021.690874 |
work_keys_str_mv | AT wuqiuji comparisonofprimaryandsecondaryprophylaxisusingpegylatedrecombinanthumangranulocytestimulatingfactorasacosteffectivemeasureinmalignantneoplasmsamulticenterretrospectivestudy AT liqiu comparisonofprimaryandsecondaryprophylaxisusingpegylatedrecombinanthumangranulocytestimulatingfactorasacosteffectivemeasureinmalignantneoplasmsamulticenterretrospectivestudy AT zhangjun comparisonofprimaryandsecondaryprophylaxisusingpegylatedrecombinanthumangranulocytestimulatingfactorasacosteffectivemeasureinmalignantneoplasmsamulticenterretrospectivestudy AT luozhumei comparisonofprimaryandsecondaryprophylaxisusingpegylatedrecombinanthumangranulocytestimulatingfactorasacosteffectivemeasureinmalignantneoplasmsamulticenterretrospectivestudy AT zhoujin comparisonofprimaryandsecondaryprophylaxisusingpegylatedrecombinanthumangranulocytestimulatingfactorasacosteffectivemeasureinmalignantneoplasmsamulticenterretrospectivestudy AT chenjing comparisonofprimaryandsecondaryprophylaxisusingpegylatedrecombinanthumangranulocytestimulatingfactorasacosteffectivemeasureinmalignantneoplasmsamulticenterretrospectivestudy AT luoyong comparisonofprimaryandsecondaryprophylaxisusingpegylatedrecombinanthumangranulocytestimulatingfactorasacosteffectivemeasureinmalignantneoplasmsamulticenterretrospectivestudy |