Cargando…

Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines

CD8+ T cells play a key role in mediating protective immunity after immune challenges such as infection or vaccination. Several subsets of differentiated CD8+ T cells have been identified, however, a deeper understanding of the molecular mechanism that underlies T-cell differentiation is lacking. Co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meldgaard, Trine Sundebo, Blengio, Fabiola, Maffione, Denise, Sammicheli, Chiara, Tavarini, Simona, Nuti, Sandra, Kratzer, Roland, Medini, Duccio, Siena, Emilio, Bertholet, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586650/ https://www.ncbi.nlm.nih.gov/pubmed/34777370 http://dx.doi.org/10.3389/fimmu.2021.757151

Ejemplares similares

Novel Platforms for the Development of a Universal Influenza Vaccine
por: Kumar, Arun, et al.
Publicado: (2018)

Systematic characterization of human response to H1N1 influenza vaccination through the construction and integration of personalized transcriptome response profiles
por: De Intinis, Carlo, et al.
Publicado: (2021)

Interplay Between Virulence and Variability Factors as a Potential Driver of Invasive Meningococcal Disease
por: Siena, Emilio, et al.
Publicado: (2018)

MF59- and Al(OH)(3)-Adjuvanted Staphylococcus aureus (4C-Staph) Vaccines Induce Sustained Protective Humoral and Cellular Immune Responses, with a Critical Role for Effector CD4 T Cells at Low Antibody Titers
por: Monaci, Elisabetta, et al.
Publicado: (2015)

Dataset of antibody variable region sequence features inferred from a respiratory syncytial virus fusion protein-specific B cell receptor repertoire induced by natural infection of a healthy adult
por: Schneikart, Gerald, et al.
Publicado: (2020)

One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4(+) T Cells, and IL-17A
por: Mancini, Francesca, et al.
Publicado: (2016)

Ex Vivo Analysis of Human Memory B Lymphocytes Specific for A and B Influenza Hemagglutinin by Polychromatic Flow-Cytometry
por: Bardelli, Monia, et al.
Publicado: (2013)

Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo
por: Nair, Nitya, et al.
Publicado: (2013)

Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells
por: Cioncada, Rossella, et al.
Publicado: (2017)

Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles
por: Grandi, Alberto, et al.
Publicado: (2017)

Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans
por: Spensieri, Fabiana, et al.
Publicado: (2016)

A quantitative systems pharmacology approach to support mRNA vaccine development and optimization
por: Selvaggio, Gianluca, et al.
Publicado: (2021)

Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination
por: Corrado, Alessia, et al.
Publicado: (2016)

Dynamics of Melanoma-Associated Epitope-Specific CD8+ T Cells in the Blood Correlate With Clinical Outcome Under PD-1 Blockade
por: Gaißler, Andrea, et al.
Publicado: (2022)

Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models
por: Grandi, Alberto, et al.
Publicado: (2018)

Staphylococcus aureus-Specific Tissue-Resident Memory CD4(+) T Cells Are Abundant in Healthy Human Skin
por: Hendriks, Astrid, et al.
Publicado: (2021)

Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms
por: Leonardelli, Lorena, et al.
Publicado: (2021)

In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes
por: Siena, Emilio, et al.
Publicado: (2016)

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy
por: Tumas, Sarunas, et al.
Publicado: (2023)

CD1d-restricted Help To B Cells By Human Invariant Natural Killer T Lymphocytes
por: Galli, Grazia, et al.
Publicado: (2003)

Selection of cell-type specific antibodies on tissue-sections using phage display
por: Larsen, Simon Asbjørn, et al.
Publicado: (2015)

Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
por: Lyauk, Yassine Kamal, et al.
Publicado: (2021)

Alum/Toll-Like Receptor 7 Adjuvant Enhances the Expansion of Memory B Cell Compartment Within the Draining Lymph Node
por: Vo, Hoa Thi My, et al.
Publicado: (2018)

Dissecting in Vitro the Activation of Human Immune Response Induced by Shigella sonnei GMMA
por: Tondi, Serena, et al.
Publicado: (2022)

Complement as an Endogenous Adjuvant for Dendritic Cell-Mediated Induction of Retrovirus-Specific CTLs
por: Bánki, Zoltán, et al.
Publicado: (2010)

Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy
por: Zimmermann, Jennifer, et al.
Publicado: (2022)

Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass
por: Raggi, Federica, et al.
Publicado: (2020)

Protein Homology Network Families Reveal Step-Wise Diversification of Type III and Type IV Secretion Systems
por: Medini, Duccio, et al.
Publicado: (2006)

Fast and accurate dynamic estimation of field effectiveness of meningococcal vaccines
por: Argante, Lorenzo, et al.
Publicado: (2016)

Chemokine-Adjuvanted Plasmid DNA Induces Homing of Antigen-Specific and Non–Antigen-Specific B and T Cells to the Intestinal and Genital Mucosae
por: Aldon, Yoann, et al.
Publicado: (2020)

Development of a Molecular Adjuvant to Enhance Antigen-Specific CD8(+) T Cell Responses
por: Halbroth, Benedict R., et al.
Publicado: (2018)

Squalene-Based Influenza Vaccine Adjuvants and Their Impact on the Hemagglutinin-Specific B Cell Response
por: Nguyen-Contant, Phuong, et al.
Publicado: (2021)

Cell-Specific Cardiac Electrophysiology Models
por: Groenendaal, Willemijn, et al.
Publicado: (2015)

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant
por: Coler, Rhea N., et al.
Publicado: (2011)

The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors
por: Andreano, Emanuele, et al.
Publicado: (2021)

Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity
por: Kreutz, Martin, et al.
Publicado: (2012)

Herrera y Reissig : del modernismo a la vanguardia
por: Blengio Brito, Raúl
Publicado: (1978)

DNA as an Adjuvant: Capacity of Insect DNA and Synthetic Oligodeoxynucleotides to Augment T Cell Responses to Specific Antigen
por: Sun, Siquan, et al.
Publicado: (1998)

Negative modulation of suppressive HIV-specific regulatory T cells by IL-2 adjuvanted therapeutic vaccine
por: Brezar, Vedran, et al.
Publicado: (2017)

Hydration and Nephrolithiasis in Pediatric Populations: Specificities and Current Recommendations
por: Injeyan, Maud, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_clqt15nigu2bidnsp31ht6j54k