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Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells

Although the inhibition of acid ceramidase (AC) is known to induce antitumor effects in various cancers, there are few reports in pancreatic cancer, and the underlying mechanisms remain unclear. Moreover, there is currently no safe administration method of AC inhibitor. Here the effects of gene ther...

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Detalles Bibliográficos
Autores principales:	Taniai, Tomohiko, Shirai, Yoshihiro, Shimada, Yohta, Hamura, Ryoga, Yanagaki, Mitsuru, Takada, Naoki, Horiuchi, Takashi, Haruki, Koichiro, Furukawa, Kenei, Uwagawa, Tadashi, Tsuboi, Kazuhito, Okamoto, Yasuo, Shimada, Shu, Tanaka, Shinji, Ohashi, Toya, Ikegami, Toru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586682/ https://www.ncbi.nlm.nih.gov/pubmed/34459070 http://dx.doi.org/10.1111/cas.15123

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