Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer

A 55-year-old woman with stage IV breast cancer was diagnosed with heart failure. Her left ventricular ejection fraction (LVEF) had decreased to 37.2%. Chemotherapy-related cardiac dysfunction (CTRCD) was suspected, and standard treatment for heart failure was initiated. After five months, her LVEF...

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Detalles Bibliográficos
Autores principales: Harada, Yuko, Shimada, Kyosuke, Kubota, Yukino, Yoshimoto, Tatsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Cardiac/Thoracic/Vascular Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586790/
https://www.ncbi.nlm.nih.gov/pubmed/34790483
http://dx.doi.org/10.7759/cureus.18731
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author Harada, Yuko
Shimada, Kyosuke
Kubota, Yukino
Yoshimoto, Tatsuji
author_facet Harada, Yuko
Shimada, Kyosuke
Kubota, Yukino
Yoshimoto, Tatsuji
author_sort Harada, Yuko
collection PubMed
description A 55-year-old woman with stage IV breast cancer was diagnosed with heart failure. Her left ventricular ejection fraction (LVEF) had decreased to 37.2%. Chemotherapy-related cardiac dysfunction (CTRCD) was suspected, and standard treatment for heart failure was initiated. After five months, her LVEF remained below 50% since she could not tolerate beta-blockers. Ivabradine was introduced, which remarkably improved her LVEF to 72.6% in only three months. Her myocardium was not dilated, which may be the reason that ivabradine was effective. Ivabradine has shown to be safe and effective in the treatment of CTRCD, and improved activities of daily living of an advanced-stage cancer patient.
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spelling pubmed-85867902021-11-16 Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer Harada, Yuko Shimada, Kyosuke Kubota, Yukino Yoshimoto, Tatsuji Cureus Cardiac/Thoracic/Vascular Surgery A 55-year-old woman with stage IV breast cancer was diagnosed with heart failure. Her left ventricular ejection fraction (LVEF) had decreased to 37.2%. Chemotherapy-related cardiac dysfunction (CTRCD) was suspected, and standard treatment for heart failure was initiated. After five months, her LVEF remained below 50% since she could not tolerate beta-blockers. Ivabradine was introduced, which remarkably improved her LVEF to 72.6% in only three months. Her myocardium was not dilated, which may be the reason that ivabradine was effective. Ivabradine has shown to be safe and effective in the treatment of CTRCD, and improved activities of daily living of an advanced-stage cancer patient. Cureus 2021-10-13 /pmc/articles/PMC8586790/ /pubmed/34790483 http://dx.doi.org/10.7759/cureus.18731 Text en Copyright © 2021, Harada et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiac/Thoracic/Vascular Surgery
Harada, Yuko
Shimada, Kyosuke
Kubota, Yukino
Yoshimoto, Tatsuji
Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer
title Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer
title_full Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer
title_fullStr Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer
title_full_unstemmed Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer
title_short Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer
title_sort ivabradine for chemotherapy-related cardiac dysfunction in breast cancer
topic Cardiac/Thoracic/Vascular Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586790/
https://www.ncbi.nlm.nih.gov/pubmed/34790483
http://dx.doi.org/10.7759/cureus.18731
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AT yoshimototatsuji ivabradineforchemotherapyrelatedcardiacdysfunctioninbreastcancer

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