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High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma

Objectives To estimate the current prevalence of bone marrow involvement in classical Hodgkin lymphoma (HL) patients diagnosed at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. Methods A cross-sectional study was conducted among classical Hodgkin’s lymphoma patients, diagnosed between...

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Autores principales: Alzahrani, Musa F, Alkahil, Mohammed B, Alhusainy, Abdulaziz A, Alangari, Abdulmohsen K, Almania, Mohammed N, Alshahrani, Essam H, Askar, Fahad I, Altowairqi, Mashael Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586905/
https://www.ncbi.nlm.nih.gov/pubmed/34790500
http://dx.doi.org/10.7759/cureus.19494
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author Alzahrani, Musa F
Alkahil, Mohammed B
Alhusainy, Abdulaziz A
Alangari, Abdulmohsen K
Almania, Mohammed N
Alshahrani, Essam H
Askar, Fahad I
Altowairqi, Mashael Y
author_facet Alzahrani, Musa F
Alkahil, Mohammed B
Alhusainy, Abdulaziz A
Alangari, Abdulmohsen K
Almania, Mohammed N
Alshahrani, Essam H
Askar, Fahad I
Altowairqi, Mashael Y
author_sort Alzahrani, Musa F
collection PubMed
description Objectives To estimate the current prevalence of bone marrow involvement in classical Hodgkin lymphoma (HL) patients diagnosed at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. Methods A cross-sectional study was conducted among classical Hodgkin’s lymphoma patients, diagnosed between 2015 and 2021 at KKUH. We retrospectively collected clinical and pathological information from all adult patients aged 18 years or older with a diagnosis of HL. Survival analyses were performed using the log-rank test and Kaplan-Meier curves. Results The study included 140 patients, 60 (42.86%) of whom were female. Bone marrow involvement was seen in 15 (10.71%) patients, 58 (41.43%) patients had an advanced-stage disease, and 20 (14.29%) patients had gastrointestinal involvement. Patients with bone marrow involvement had a median survival of 71 months (95% confidence interval (CI): 16.7-125.3) compared to patients without bone marrow involvement who had a median survival of 68 months (95% CI: 50.7-85.3). Conclusion The prevalence of bone marrow involvement in HL patients, as well as the proportion of patients presenting with advanced disease at the time of diagnosis, was higher compared to Western data. This could be attributed to a delay in diagnosis or more aggressive disease biology.
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spelling pubmed-85869052021-11-16 High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma Alzahrani, Musa F Alkahil, Mohammed B Alhusainy, Abdulaziz A Alangari, Abdulmohsen K Almania, Mohammed N Alshahrani, Essam H Askar, Fahad I Altowairqi, Mashael Y Cureus Internal Medicine Objectives To estimate the current prevalence of bone marrow involvement in classical Hodgkin lymphoma (HL) patients diagnosed at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. Methods A cross-sectional study was conducted among classical Hodgkin’s lymphoma patients, diagnosed between 2015 and 2021 at KKUH. We retrospectively collected clinical and pathological information from all adult patients aged 18 years or older with a diagnosis of HL. Survival analyses were performed using the log-rank test and Kaplan-Meier curves. Results The study included 140 patients, 60 (42.86%) of whom were female. Bone marrow involvement was seen in 15 (10.71%) patients, 58 (41.43%) patients had an advanced-stage disease, and 20 (14.29%) patients had gastrointestinal involvement. Patients with bone marrow involvement had a median survival of 71 months (95% confidence interval (CI): 16.7-125.3) compared to patients without bone marrow involvement who had a median survival of 68 months (95% CI: 50.7-85.3). Conclusion The prevalence of bone marrow involvement in HL patients, as well as the proportion of patients presenting with advanced disease at the time of diagnosis, was higher compared to Western data. This could be attributed to a delay in diagnosis or more aggressive disease biology. Cureus 2021-11-12 /pmc/articles/PMC8586905/ /pubmed/34790500 http://dx.doi.org/10.7759/cureus.19494 Text en Copyright © 2021, Alzahrani et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Alzahrani, Musa F
Alkahil, Mohammed B
Alhusainy, Abdulaziz A
Alangari, Abdulmohsen K
Almania, Mohammed N
Alshahrani, Essam H
Askar, Fahad I
Altowairqi, Mashael Y
High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma
title High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma
title_full High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma
title_fullStr High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma
title_full_unstemmed High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma
title_short High Prevalence of Bone Marrow Involvement and Advanced Disease in Saudi Patients Diagnosed With Hodgkin Lymphoma
title_sort high prevalence of bone marrow involvement and advanced disease in saudi patients diagnosed with hodgkin lymphoma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586905/
https://www.ncbi.nlm.nih.gov/pubmed/34790500
http://dx.doi.org/10.7759/cureus.19494
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